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    Marbofloxacin
    Marbofloxacin

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1422
    CAS #: 115550-35-1Purity ≥98%

    Description: Marbofloxacin (Forcyl, Kelacyl, Zeniquin, Aristos, Boflox, Marbocyl, Aurizon), a carboxylic acid derivative, is a 3rd generation and broad spectrum antibiotic of the fluoroquinolone class used as a veterinary medication. Marbofloxacin demonstrated significant antibiotic effects against both gram–and + bacteria. 

    References: Vet Parasitol. 2006 Jan 30;135(2):137-46; J Vet Pharmacol Ther. 2006 Dec;29(6):555-60.

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    Molecular Weight (MW)362.36 
    FormulaC17H19FN4O4 
    CAS No.115550-35-1 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 3 mg/mL (8.3 mM) 
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Solubility (In vivo)1% DMSO+30% polyethylene glycol+1% Tween 80, pH 4: 14 mg/mL
    SynonymsZeniquin, Forcyl, Kelacyl, Zeniquin, Aristos, Boflox, Marbocyl, Aurizon


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    In Vitro

    In vitro activity: Marbofloxacin is a fluoroquinolone antimicrobial agent developed exclusively for veterinary use. Marbofloxacin exhibits high bactericidal activity against a broad spectrum of aerobic Gram-negative and some Gram-positive bacteria, as well as Mycoplasma spp. As the third generation fluoroquinolone, Marbofloxacin also mainly targets replication and transcription enzymes such as DNA gyrase and topoisomerase IV, which are both essential for bacterial viability. Marbofloxacin has a mycoplasmacidal effect during the exponential phase but not during the lag phase, in both the M. hyopneumoniae 116 wild-type strain and a clone isolated 4 days post-marbofloxacin treatment in vivo at the therapeutic dose. Marbofloxacin significantly kills Leishmania promastigotes and intracellular amastigotes in a dose-dependent manner, more efficient than meglumine antimoniate and sodium stibogluconate. After treatment with Marbofloxacin, macrophages acquire resistance to infection and enhanced antileishmanial activity through the NO synthase pathway.

    In VivoMarbofloxacin treatment at the therapeutic dose does not eliminate M. hyopneumoniae, with 87.5 to 100% of the pigs still positive at the end of the assays, and is not effective in significantly reducing clinical signs. Nevertheless, Marbofloxacin treatment seems to decrease the lung lesion scores. Administration of Marbofloxacin at 6 mg/kg once daily for 7 days in a Staphylococcus aureus infection in tissue cages in ponies is not effective for the elimination of S. aureus infections from secluded sites. 
    Animal modelSPF piglets inoculated intratracheally with M. hyopneumoniae strain 116 
    Formulation & DosageDissolved DMSO, and diluted in saline; 2 mg/kg/day; i.m. injection 
    References

    Vet Parasitol. 2006 Jan 30;135(2):137-46; J Vet Pharmacol Ther. 2006 Dec;29(6):555-60. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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