Marbofloxacin

Alias: Zeniquin; Forcyl; Kelacyl; Zeniquin; Aristos; Boflox; Marbocyl; Aurizon
Cat No.:V1422 Purity: ≥98%
Marbofloxacin (Forcyl, Kelacyl,Zeniquin, Aristos, Boflox, Marbocyl, Aurizon), a carboxylic acid derivative, is a 3rd generation and broad spectrum antibiotic of the fluoroquinolone class used as a veterinary medication.
Marbofloxacin Chemical Structure CAS No.: 115550-35-1
Product category: Topoisomerase
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
250mg
500mg
1g
2g
5g
10g
Other Sizes

Other Forms of Marbofloxacin:

  • Marbofloxacin hydrochloride
Official Supplier of:
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Alternate Text
Top Publications Citing lnvivochem Products
Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Marbofloxacin (Forcyl, Kelacyl, Zeniquin, Aristos, Boflox, Marbocyl, Aurizon), a carboxylic acid derivative, is a 3rd generation and broad spectrum antibiotic of the fluoroquinolone class used as a veterinary medication. Marbofloxacin showed notable antibacterial activity against both gram–and + bacteria.

Biological Activity I Assay Protocols (From Reference)
Targets
Topoisomerase IV; Topoisomerase II
ln Vitro

Marbofloxacin is an antimicrobial fluoroquinolone that was created specifically for veterinary use. High bactericidal activity is demonstrated by marbofloxacin against Mycoplasma spp. and a wide range of aerobic Gram-negative and some Gram-positive bacteria. Marbofloxacin, a third-generation fluoroquinolone, primarily targets enzymes involved in transcription and replication, including DNA gyrase and topoisomerase IV, both of which are critical to the survival of bacteria. During the exponential phase, but not the lag phase, marbofloxacin exhibits a mycoplasmacidal effect on M. hyopneumoniae 116 wild-type strain and a clone that was isolated 4 days after in vivo treatment with the therapeutic dose.[1] In a dose-dependent manner, marbofloxacin significantly kills Leishmania promastigotes and intracellular amastigotes, outperforming sodium stibogluconate and meglumine antimoniate. Following Marbofloxacin therapy, the NO synthase pathway confers enhanced antileishmanial activity and infection resistance in macrophages.[2]

ln Vivo
Marbofloxacin treatment at the therapeutic dose is not effective in significantly reducing clinical signs and does not eradicate M. hyopneumoniae, as 87.5 to 100% of the pigs remain positive at the conclusion of the assays. However, treatment with marbofloxacin appears to lower the lung lesion scores.[1] Treating a Staphylococcus aureus infection in tissue cages in ponies with a once-daily dose of marbofloxacin at a dose of 6 mg/kg for seven days does not effectively eradicate S. aureus infections from isolated locations.[3]
Animal Protocol
SPF piglets inoculated intratracheally with M. hyopneumoniae strain 116
~2 mg/kg/day
Intramuscular injection
References

[1]. Marbofloxacin. Acta Crystallogr Sect E Struct Rep Online. 2012 Apr 1;68(Pt 4):o998-9.

[2]. Clinical efficacy of intravenous administration of marbofloxacin in a Staphylococcus aureus infection in tissue cages in ponies. J Vet Pharmacol Ther. 2006 Dec;29(6):555-60.

[3]. Pharmacokinetics of marbofloxacin in horses. Equine Vet J. 2002 Jul;34(4):366-72.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C17H19FN4O4
Molecular Weight
362.36
Exact Mass
362.14
Elemental Analysis
C, 56.35; H, 5.29; F, 5.24; N, 15.46; O, 17.66
CAS #
115550-35-1
Appearance
Solid powder
SMILES
CN1CCN(CC1)C2=C(C=C3C4=C2OCN(N4C=C(C3=O)C(=O)O)C)F
InChi Key
BPFYOAJNDMUVBL-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H19FN4O4/c1-19-3-5-21(6-4-19)14-12(18)7-10-13-16(14)26-9-20(2)22(13)8-11(15(10)23)17(24)25/h7-8H,3-6,9H2,1-2H3,(H,24,25)
Chemical Name
7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1,2-diazatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
Synonyms
Zeniquin; Forcyl; Kelacyl; Zeniquin; Aristos; Boflox; Marbocyl; Aurizon
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: ~3 mg/mL (~8.3 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In Vivo)
1%DMSO+30% polyethylene glycol+1%Tween 80, pH 4: 14mg/mL
 (Please use freshly prepared in vivo formulations for optimal results.)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.7597 mL 13.7984 mL 27.5969 mL
5 mM 0.5519 mL 2.7597 mL 5.5194 mL
10 mM 0.2760 mL 1.3798 mL 2.7597 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

  • Calculate the Mass of a compound required to prepare a solution of known volume and concentration
  • Calculate the Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Calculate the Concentration of a solution resulting from a known mass of compound in a specific volume
An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?
  • Enter 350.26 in the Molecular Weight (MW) box
  • Enter 10 in the Concentration box and choose the correct unit (mM)
  • Enter 5 in the Volume box and choose the correct unit (mL)
  • Click the “Calculate” button
  • The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
  • Enter 10 into the Concentration (Start) box and choose the correct unit (mM)
  • Enter 25 into the Concentration (End) box and select the correct unit (mM)
  • Enter 25 into the Volume (End) box and choose the correct unit (mL)
  • Click the “Calculate” button
  • The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box
g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
Instructions to calculate molar mass (molecular weight) of a chemical compound:
  • To calculate molar mass of a chemical compound, please enter the chemical/molecular formula and click the “Calculate’ button.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
  • Molecular mass (or molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
  • Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
/

Reconstitution Calculator allows you to calculate the volume of solvent required to reconstitute your vial.

  • Enter the mass of the reagent and the desired reconstitution concentration as well as the correct units
  • Click the “Calculate” button
  • The answer appears in the Volume (to add to vial) box
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)
+
+
+

Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

Biological Data
  • Molecular structure of marbofloxacin showing atom-labelling scheme and displacement ellipsoids at 40% probability level. H atoms are shown as small circles of arbitary radii. Acta Crystallogr Sect E Struct Rep Online . 2012 Apr 1;68(Pt 4):o998-9.
  • Part of the crystal packing of Marbofloxacin. Acta Crystallogr Sect E Struct Rep Online . 2012 Apr 1;68(Pt 4):o998-9.
Contact Us