Topoisomerases are enzymes that regulate the overwinding or underwinding of DNA.DNA's double-helical structure is entwined, which leads to the winding issue. Isomerization enzymes called topoisomerases work on DNA's topology. One strand of a DNA double helix is cut by type I topoisomerase, which is followed by relaxation and reannealing of the cut strand. Type I topoisomerases are divided into two subclasses: type IB topoisomerases, which employ a controlled rotary mechanism, and type IA topoisomerases, which share many structural and mechanistic features with the type II topoisomerases. One DNA double helix's two strands are cut by Type II topoisomerase, which then reanneals the cut strands after passing through another DNA double helix that hasn't been broken. Type IIA and type IIB topoisomerases, two subclasses of this class with related structures and mechanisms, are further divided.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
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V1409 | Norfloxacin (MK-0366) | 70458-96-7 | Norfloxacin (AM-715; MK 0366; MK0366; AM715; MK-366; AM 715; MK366; MK 366; Noroxin; Chibroxin) is a broad-spectrum and synthetic chemotherapeuticantibiotic approved for the treatment of UTIs-urinary tract infections. |
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V1414 | Novobiocin Sodium (Albamycin; Cathomycin) | 1476-53-5 | Novobiocin Sodium (formerly known as U6591, U-6591, Cathomycin, Inabiocin, Albadry, Streptonivicin, Albamycin) is a novel and potent antibiotic of the aminocoumarin class isolated from Streptomyces niveus and used for bacterial infections. |
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V1418 | Ofloxacin (Hoe-280; DL8280) | 82419-36-1 | Ofloxacin (Hoe-280; DL8280; DL-8280, DR-3355, Hoe280, ORF-28489, Ru-43280) is a synthetic, orally bioavailable and broad-spectrum antibiotic of the fluorinated quinolone class used for the treatment of a variety of bacterial infections such as pneumonia, cellulitis, UTIs-urinary tract infections, prostatitis, and plague. |
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V1408 | Pefloxacin Mesylate Dihydrate | 149676-40-4 | Pefloxacin mesylate dihydrate (Peflacine;1589-RB; 1589RB;UNII-CX28QC6FU0; Peflacin; Pefloxacinium), the mesylate salt and dihydrated form of pefloxacin, is abroad-spectrum and 3rd generation fluoroquinolone antibiotic approved for treating bacterial infections. |
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V1419 | Pirarubicin (THP) | 72496-41-4 | Pirarubicin (THP; THPADM; THPDOX; 1609RB; THP-Adriamycin; THP-Doxorubicin; Pinorubicin; Theprubicine; Therarubicin) is an analog of anthracycline with potential antitumor activity. |
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V0068 | Pixantrone (BBR-2778 | 144510-96-3 | Pixantrone (formerly known as BBR 2778), is a novel, potent aza-anthracenedione analog with anticancer activity with little cardiotoxicity. |
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V0067 | Pixantrone dimaleate (BBR-2778) | 144675-97-8 | Pixantrone dimaleate, the dimaleate salt of Pixantrone (formerly known as BBR 2778) and an aza-anthracenedione analog, is a weaktopoisomerase IIinhibitor and DNA intercalator with anticancer activity with little cardiotoxicity. |
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V2336 | PluriSIn #2 | 56563-17-8 | PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II alpha (TOP2A). |
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V8907 | Rubitecan | 91421-42-0 | Rubitecan(RFS-2000), a semisynthetic camptothecin analog, is an orally bioactive topoisomerase I inhibitor antitumor and antiviral activity. |
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V75879 | SDOX | 2921601-78-5 | SDOX is the precursor active molecule of Doxorubicin. |
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V1397 | SN-38 (NK012) | 86639-52-3 | SN-38 (NK012; SN-38; NK-012; SN 38; 10-hydroxy-7-ethylcamptothecin) is the active metabolite of Irinotecan (CPT-11) which is a Topoisomerase I inhibitor approved for use as an anticancer drug. |
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V2051 | TAS-103 (BMS-247615) | 174634-08-3 | TAS-103 (also known as BMS-247615) is a potent and dual inhibitor of DNA topoisomerase I/II. |
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V2860 | TAS-103 dihydrochloride | 174634-09-4 | TAS-103 dihydrochloride (also known as BMS-247615) is a potent and dual inhibitor of DNA topoisomerase I/II. |
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V1406 | Teniposide (VM-26) | 29767-20-2 | Teniposide (VM-26;HSDB-6546;NSC-122819; CCRIS-2058; Vumon; Vehem; EPT; PTG)is a semisynthetic podophyllotoxin derivative and chemotherapeuticagent mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). |
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V75882 | Topoisomerase I inhibitor 9 | 1228150-86-4 | Topoisomerase I inhibitor 9 (compound 3d) is a leishmanial topoisomerase IB inhibitor. |
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V75884 | Topoisomerase I/II inhibitor 2 | 2770804-58-3 | Topoisomerase I/II inhibitor 2 (compound 1a) is a potent topoisomerase inhibitor (antagonist) with IC50 of 9.82 μM and 6.83 μM in Huh7 and LM9 cells respectively. |
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V1392 | Topotecan HCl (SKF 104864A) | 119413-54-6 | Topotecan HCl (formerly known as NSC609699, Nogitecan, NSC-609699,SKFS-104864A; trade name: Hycamtin), an FDA approved drug for cancer treatment, is a topoisomerase I inhibitor with potent antineoplastic activity. |
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V1396 | Voreloxin (SNS-595) HCl | 175519-16-1 | Voreloxin HCl (formerly known as AG-7352;SNS-595;SPC 595; AG 7352;SNS595,AG-7352; Vosaroxin), the hydrochloride salt of Voreloxin which is anaphthyridine analog, is a novel and potent Topoisomerase II inhibitor with a broad-spectrum antineoplastic activity. |
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