TRP Channels are a group of ion channels that are primarily found on the plasma membrane of various types of human and animal cells. There are about 28 TRP channels, and many of them are structurally related to one another. These are divided into two major categories: TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA are all members of Group 1. There are two members of group 2: TRPP (for polycystic) and TRPML (for mucolipin). A large number of these channels mediate a wide range of sensations, including pain, hotness, warmth, or coldness, various tastes, pressure, and vision. Cations like sodium, calcium, and magnesium are relatively non-selectively permeable to TRP channels. The fruit fly Drosophila trp-mutant strain is where TRP channels were first identified. TRP channels are later discovered in vertebrates, where they are widely expressed in a variety of cell types and tissues. TRP channels are crucial for human health because at least four diseases are caused by mutations in these channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2999 | Icilin | 36945-98-9 | Icilin (also known as AG-3-5 or AG 3-5) is a synthetic CMR1/TRPM8 (transient receptor potential M8) super-cooling agent/agonist that is 2.5-fold more efficacious and nearly 200-fold more potent than the reference cold thermosensory agonist, l-menthol. |
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V4502 | JNJ-17203212 | 821768-06-3 | JNJ-17203212 is a novel, potent, reversible, competitive and selective TRPV1 antagonist with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. |
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V70155 | JNJ-28583113 | 2765255-93-2 | JNJ-28583113 is a brain-permeable (penetrable) TRPM2 antagonist. |
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V70127 | KM-001 | 2682864-35-1 | KM-001 is a potent and specific TRPV3 antagonist. |
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V70170 | L-R4W2 | 206350-79-0 | L-R4W2 is a potent vanillic acid receptor 1 (VR1, TRPV1) antagonist (inhibitor) with IC50 of 0.1 μM. |
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V80622 | L-R4W2 TFA | L-R4W2 TFA is a potent vanillic acid receptor 1 (VR1, TRPV1) antagonist (inhibitor) with IC50 of 0.1 μM. | |
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V70160 | M8-B | 883976-12-3 | M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. |
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V4517 | Mavatrep | 956274-94-5 | Mavatrep (formerly known as JNJ-39439335) is a novel, orally bioavailable, potent and selective TRPV1 antagonist (Ki = 6.5 nM) with a potential to manageinflammatory pain. |
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V2184 | MDR-652 | 1933528-96-1 | MDR-652 is a novel and highly specific and efficacious transient receptor potential vanilloid 1 (TRPV1) ligand with agonist activity. |
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V70175 | Methyl kakuol | 70342-29-9 | Methyl kakuol has an activating effect on TRPA1 with EC50 of 0.27 µM. |
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V70138 | Methyl syringate-d6 | 1182838-09-0 | Methyl syringate-d6 is the deuterated form of Methyl syringate. |
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V70171 | MK-2295 (NGD-8243) | 573678-04-3 | MK-2295 (NGD-8243) is a TRPV1 antagonist. |
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V41526 | ML-SA1 | 332382-54-4 | ML-SA1 is a potent agonist of TRPML1 (transient receptor potential mucolipin 1) with broad spectrum of antiviral activity. |
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V76760 | ML-SI1 | ML-SI1, a racemic mixture (racemate) of diastereoisomers, is a TRPML inhibitor (antagonist) with IC50 of 15 μM for TRPML1. | |
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V2491 | ML-SI3 | 891016-02-7 | ML SI3 (ML-SI3) isan antagonist of the TRPML family of calcium channels. |
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V4004 | ML204 | 5465-86-1 | ML204 is a novel, potent, and selective TRPC4 (Transient receptor potential canonical) channel inhibitor identified from high throughput fluorescent screen of 305,000 compounds of the Molecular Libraries Small Molecule Repository for inhibitors that blocked intracellular Ca(2+) rise in response to stimulation of mouse TRPC4β by μ-opioid receptors. |
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V4005 | ML204 HCl | 2070015-10-8 | ML204 HCl is a novel, potent, and selective TRPC4 (Transient receptor potential canonical) channel inhibitor identified from high throughput fluorescent screen of 305,000 compounds of the Molecular Libraries Small Molecule Repository for inhibitors that blocked intracellular Ca(2+) rise in response to stimulation of mouse TRPC4β by μ-opioid receptors. |
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V70114 | Moringin (moringin) | 73255-40-0 | Moringin is a potent and specific natural agonist of the TRPA1 ion channel with EC50 of 3.14 μM. |
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V70150 | Murpanicin (Murraxocin) | 88478-44-8 | Murpanicin (murraxocin) is a coumarin and a thermosensitive transient receptor potential vanilloid 2 (TRPV2) channel inhibitor. |
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V70145 | N-Oleoyl glutamine | 247150-73-8 | N-oleoyl-glutamine is an N-acyl amino acid (AA) (NAAs) regulated by PM20D1. |
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