TRP Channels are a group of ion channels that are primarily found on the plasma membrane of various types of human and animal cells. There are about 28 TRP channels, and many of them are structurally related to one another. These are divided into two major categories: TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA are all members of Group 1. There are two members of group 2: TRPP (for polycystic) and TRPML (for mucolipin). A large number of these channels mediate a wide range of sensations, including pain, hotness, warmth, or coldness, various tastes, pressure, and vision. Cations like sodium, calcium, and magnesium are relatively non-selectively permeable to TRP channels. The fruit fly Drosophila trp-mutant strain is where TRP channels were first identified. TRP channels are later discovered in vertebrates, where they are widely expressed in a variety of cell types and tissues. TRP channels are crucial for human health because at least four diseases are caused by mutations in these channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V70149 | Bisandrographolide C (Bisandrographolide C) | 160498-02-2 | Bisandrographolide C is a unique dimer isolated and identified from Andrographis paniculata. |
|
V17503 | Capsaicin ((E)-Capsaicin) | 404-86-4 | Capsaicin ((E)-Capsaicin),a mixture of Capsaicin and Dihydrocapsaicin, is an active component isolatedd from chili peppers, which are plants belonging to the genus Capsicum, acting as a TRPV1 agonist with an EC50 of 0.29 μM in HEK293 cells. |
|
V2715 | Capsazepine | 138977-28-3 | Capsazepine is a novel, potent and synthetic antagonist of TRPM8 channels (IC50 = 562 nM) with potential anticancer activity. |
|
V70166 | Capsiate | 205687-01-0 | Capsiate is a capsaicin analog derived from the CH-19 non-irritating sweet red pepper variety and is an orally bioactive TRPV1 agonist. |
|
V70137 | Capsiconiate (Coniferyl (E)-8-methyl-6-nonenoate) | 946572-73-2 | Capsiconiate (Coniferyl (E)-8-methyl-6-nonenoate) is a TRPV1 agonist (EC50= 3.2 μM). |
|
V78708 | CEDAEVFKDSMVPGEK | CEDAEVFKDSMVPGEK is a rat capsaicin receptor subtype 1 (VR1) peptide sequence fragment that may be utilized to detect the presence, distribution and molecular morphology of VR1. | |
|
V79956 | Clemizole-d4 | Clemizole-d4 is a deuterated form of Clemizole. | |
|
V70161 | D-erythro-Sphingosine hydrochloride (Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride) | 2673-72-5 | D-erythro-Sphingosine (Erythrosphingosine) HCl is a specific TRPM3 activator. |
|
V32020 | Dihydrocapsaicin | 19408-84-5 | Dihydrocapsaicin is a naturally occuring capsaicin isolated from Capsicum fruit, it acts as a potent and selective TRPV1 agonist, and also increases p-Akt levels. |
|
V70172 | Dihydrocapsiate | 205687-03-2 | Dihydrocapsiate, a compound of the dihydrocapsinoid family, is an orally bioactive TRPV1 agonist. |
|
V70144 | Diisopropyl adipate (Adipic acid diisopropyl ester) | 6938-94-9 | Diisopropyl adipate is an alternative plasticizer and TRPA1 activator. |
|
V70117 | Evifacotrep | 2413739-88-3 | Evfacotrep is a short-term transient receptor potential channel 5 (TRPC5) antagonist (WO2020061162, compound 100) that may be utilized in the study of neurological diseases. |
|
V70135 | GDC-0334 | 1984824-54-5 | GDC-0334 is a TRPA1 selective antagonist. |
|
V70128 | GDC-6599 | 2376824-99-4 | GDC-6599 (Example 8) is an orally bioavailable TRPA1 inhibitor. |
|
V40197 | GFB-8438 | 2304549-73-1 | GFB-8438 is a novel, highly potent and subtype specific TRPC5 inhibitor with IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. |
|
V3576 | GSK1016790A | 942206-85-1 | GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) activator. |
|
V3556 | GSK2193874 | 1336960-13-4 | GSK2193874 (GSK-2193874) is a novel, potent, orally bioactive, and selectiveTRPV4 (Transient Receptor Potential Vanilloid 4)antagonist with the potential to be used forcongestive heart failure. |
|
V0023 | HC-030031 (TOSLAB-829227) | 349085-38-7 | HC-030031 (also known as TOSLAB 829227)is a novel, potent and selective blocker/antagonist/inhibitor of TRPA1 (transient receptor potential ankyrin 1) channel. |
|
V22085 | HC-070 | 1628291-95-1 | HC-070 is a novel and potent inhibitor of TRPC4 and TRPC5 with IC50s of 9.3 nM and 46 nM for hTRPC5 and hTRPC4 in cell assay. |
|
V70130 | Hyp9 | 3118-34-1 | Hyp9 is a transient receptor potential cation channel 6 (TRPC6) specific agonist. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
