TRP Channels are a group of ion channels that are primarily found on the plasma membrane of various types of human and animal cells. There are about 28 TRP channels, and many of them are structurally related to one another. These are divided into two major categories: TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA are all members of Group 1. There are two members of group 2: TRPP (for polycystic) and TRPML (for mucolipin). A large number of these channels mediate a wide range of sensations, including pain, hotness, warmth, or coldness, various tastes, pressure, and vision. Cations like sodium, calcium, and magnesium are relatively non-selectively permeable to TRP channels. The fruit fly Drosophila trp-mutant strain is where TRP channels were first identified. TRP channels are later discovered in vertebrates, where they are widely expressed in a variety of cell types and tissues. TRP channels are crucial for human health because at least four diseases are caused by mutations in these channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V2381 | TRPV4 agonist-1 | 2314467-59-7 | TRPV4 agonist-1 free base is a transient receptor potential vanilloid isoform 4 (TRPV4) agonist with EC50 of 60 nM in hTRPV4 Ca2+ assays. |
|
V70139 | TRPV4 antagonist 3 | 2681273-35-6 | TRPV4 antagonist 3 is a TRPV4 antagonist (pIC50 = 8.4). |
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V70169 | TRPV4 antagonist 4 | 2918803-89-9 | TRPV4 antagonist 4 is a potent TRPV4 antagonist (inhibitor) with IC50 of 22.65 nM. |
|
V70165 | Vanilloid receptor antagonist 1 | 871814-52-7 | Vanilloid receptor antagonist 1 is a potent vanilloid receptor (TRPV1) antagonist. |
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V70118 | Voacangine | 510-22-5 | Voacangine is an antagonist of TRPV1 and TRPM8, but also an agonist of TRPA1 (EC50=8 μM). |
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V70141 | Vocacapsaicin (CA-008) | 1931116-86-7 | Vocacapsaicin (CA-008), the precursor of capsaicin, is the first non-opioid TRPV1 agonist. |
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V70146 | Vocacapsaicin hydrochloride (CA-008 hydrochloride) | 1931116-92-5 | Vocacapsaicin (CA-008) HCl, the precursor of capsaicin, is the first non-opioid TRPV1 agonist. |
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V57779 | VPC01091.4 (VPC4) | 945604-76-2 | VPC01091.4 is a TRPM7 inhibitor. |
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V70158 | Xeniafaraunol A | 161162-29-4 | Xeniafaraunol A (compound 31) is a potent inhibitor of transient receptor potential melastatin 7 (TRPM7). |
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V7720 | Zucapsaicin (Civamide; cis-Capsaicin) | 25775-90-0 | Zucapsaicin (Civamide; cis-Capsaicin) is the cis isomer of capsaicin which is an orally bioactive TRPV1 agonist and a medication used to treat osteoarthritis of the knee and other neuropathic pain. |
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