TRP Channels are a group of ion channels that are primarily found on the plasma membrane of various types of human and animal cells. There are about 28 TRP channels, and many of them are structurally related to one another. These are divided into two major categories: TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA are all members of Group 1. There are two members of group 2: TRPP (for polycystic) and TRPML (for mucolipin). A large number of these channels mediate a wide range of sensations, including pain, hotness, warmth, or coldness, various tastes, pressure, and vision. Cations like sodium, calcium, and magnesium are relatively non-selectively permeable to TRP channels. The fruit fly Drosophila trp-mutant strain is where TRP channels were first identified. TRP channels are later discovered in vertebrates, where they are widely expressed in a variety of cell types and tissues. TRP channels are crucial for human health because at least four diseases are caused by mutations in these channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V16878 | Trovafloxacin mesylate | 147059-75-4 | Trovafloxacinmesylate (CP-99219) is a broad-spectrum quinolone antibiotic thatinhibits DNA supercoiling in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. |
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V70131 | TRPA1 Antagonist 3 | 71291-80-0 | TRPA1 Antagonist 3 is a light-controllable TRPA1 agonist that provides optical control of TRPA1 channels. |
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V70121 | TRPA1-IN-1 | 2376824-92-7 | TRPA1-IN-1 is a selective and orally bioactive small molecule antagonist of TRPA1. |
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V70174 | TRPA1-IN-2 | 2415206-22-1 | TRPA1-IN-2 (compound 1) is a potent orally bioactive TRPA1 inhibitor (antagonist) with IC50 of 0.04 µM. |
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V70151 | TRPC3/6-IN-2 | 2387893-55-0 | TRPC3/6-IN-2 is a potent TRPC3/6 inhibitor (antagonist) with IC50s of 16 nM and 29.8 nM for TRPC3 and TRPC6, respectively. |
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V70125 | TRPC5-IN-1 | 2265215-18-5 | TRPC5-IN-1 (Compound 6j) is a selective TRPC5 inhibitor that can suppress TRPC5 by 50.5% at 3 μM. |
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V70156 | TRPC5-IN-4 | 2762315-39-7 | TRPC5-IN-4 is a potent and safe TRPC inhibitor (antagonist) with IC50s of 14.07 nM and 65 nM for TRPC5 and TRPC4, respectively. |
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V70143 | TRPC6-IN-2 | 2308595-83-5 | The compound inhibits the TRPC protein, more specifically, the TRPC6 protein. |
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V70129 | TRPC6-IN-3 | 2311863-36-0 | TRPC6-IN-3 (compound 17) is an orally bioavailable transient receptor potential C6 ion channel (TRPC6) inhibitor. |
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V70116 | TRPC6-PAM-C20 | 667427-75-0 | TRPC6-PAM-C20 is a selective PAM (positive allosteric modulator) of TRPC6 channels. |
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V16890 | TRPM4-IN-5 | 351424-20-9 | TRPM4-IN-1 (CBA) is a potent and specific inhibitor of the cation channel TRPM4 with IC50 of 1.5 μM. |
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V31167 | TRPM8 antagonist 2 | 259674-19-6 | TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes. |
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V70124 | TRPM8 antagonist 3 | 2102179-29-1 | TRPM8 antagonist 3 is a novel TRPM8 blocker with IC50 of 11 nM. |
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V70157 | TRPM8-IN-1 | 1159996-20-9 | TRPM8-IN-1 (example 14) is a transient receptor potential melatonin TRPM8 inhibitor (antagonist) with IC50<5 μM. |
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V70136 | TRPV1 activator-1 | 1803181-80-7 | TRPV1 activator-1 (compound 8) is a capsaicin analog with an altered neck structure. |
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V70148 | TRPV1 activator-2 | 17514-11-3 | TRPV1 activator-2 (compound 9) is a capsaicin head analog that specifically interacts with channel residues at the lipid-water junction. |
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V70159 | TRPV1 antagonist 3 | 2765294-54-8 | TRPV1 antagonist 3 (Compound 7q) is a potent TRPV1 antagonist (inhibitor) with IC50 of 2.66 nM for capsaicin. |
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V70164 | TRPV2-selective blocker 1 | 2242724-49-6 | TRPV2-selective blocker 1 (compound IV2-1) is a selective TRPV2 channel blocker with IC50 of 6.3 μM. |
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V70168 | TRPV3 antagonist 74a | 1432051-63-2 | TRPV3 antagonist 74a is a potent and specific TRPV3 antagonist. |
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V2268 | TRPV4 agonist | 2314467-60-0 | TRPV4 agonist (no formal name), is a novel and potent agonist of TRPV4 with EC50 of 60 nM in the hTRPV4 Ca2+ assay |
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