TRP Channels are a group of ion channels that are primarily found on the plasma membrane of various types of human and animal cells. There are about 28 TRP channels, and many of them are structurally related to one another. These are divided into two major categories: TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA are all members of Group 1. There are two members of group 2: TRPP (for polycystic) and TRPML (for mucolipin). A large number of these channels mediate a wide range of sensations, including pain, hotness, warmth, or coldness, various tastes, pressure, and vision. Cations like sodium, calcium, and magnesium are relatively non-selectively permeable to TRP channels. The fruit fly Drosophila trp-mutant strain is where TRP channels were first identified. TRP channels are later discovered in vertebrates, where they are widely expressed in a variety of cell types and tissues. TRP channels are crucial for human health because at least four diseases are caused by mutations in these channels.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V70133 | N-Oleoyl valine | 60374-41-6 | N-Oleoyl valine is an N-acyl valine compound that works as a TRPV3 antagonist. |
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V69911 | Naltriben | 111555-58-9 | Naltriben is a selective δ2-opioid receptor antagonist and TRPM7 activator. |
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V15471 | Nonivamide | 2444-46-4 | Nonivamide is an agonist with a 4d-EC50 of 5.1 mg/L in static toxicity assays. |
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V70153 | Oleoyl serotonin | 1002100-44-8 | Oleoyl Serotonin is a TRPV1 antagonist (inhibitor) with IC50 of 2.57 μM for human TRPV1. |
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V26922 | Ononetin | 487-49-0 | Ononetin, a naturally occurring deoxybenzoinisolated from the Russian traditional medicine plant Ononis spinosa,is a novel and potent TRPM3 (transient receptor potential melastatin 3) channel blocker (IC50=300 nM). |
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V70134 | OptoBI-1 | 2415272-11-4 | OptoBI-1 is a photochromic TRPC3 agonist that may serve as a photopharmacological tool to control neuronal firing. |
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V1910 | Optovin | 348575-88-2 | Optovin is a potent and reversible photoactivated TRPA1 activator that is able to activate human TRPA1 via structure dependent photochemical reactions. |
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V81846 | p-NH2-CHX-A"-DTPA | 1105741-38-5 | p-NH2-CHX-A"-DTPA is a bifunctional chelating agent. |
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V4431 | PF-4840154 | 1332708-14-1 | PF-4840154 is a novel, potent, selective agonist of the rat and humanTrpA1channel withEC50s of 97 and 23 nM, respectively. |
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V73672 | Phenamil methanesulfonate | 1161-94-0 | Phenamil methanesulfonate is an analogue of Amiloride, a more potent and irreversible epithelial sodium channel (ENaC) blocker with IC50 of 400 nM. |
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V13408 | Pyr6 | 245747-08-4 | Pyr6 is a selective inhibitor of the ion channel TRPC3 with IC50 of 0.49uM. |
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V70126 | Resolvin D2-d5 (RvD2-d5) | 1881277-33-3 | Resolvin D2-d5 is the deuterium labelled form of Resolvin D2. |
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V13838 | RN1747 | 1024448-59-6 | RN1747 is a selective TRPV4 agonist (EC50 are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). |
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V14339 | SAR-7334 HCl | 1333207-63-8 | SAR7334 is a novel, potent and orally bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. |
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V2819 | SB-366791 | 472981-92-3 | SB-366791 is a competitive and selective cinnamide TRPV1 (Vanilloid receptor 1) antagonist identified via high-throughput screening of a large chemical library. |
|
V70163 | SET2 | 2313525-20-9 | SET2 is a selective TRPV2 antagonist (IC50=0.46 μM). |
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V14812 | SKF-96365 HCl | 130495-35-1 | SKF-96365 HCl (SKF-96365 hydrochloride) is a novel, potent and selective TRPC channel blocker that is commonly used to characterize the potential functions of TRPC channels in different systems. |
|
V76491 | SOR-C13 TFA | SOR-C13 TFA, a carboxyl-terminal truncated peptide, is a high-affinity TRPV6 antagonist (inhibitor) with IC50 of 14 nM. | |
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V70120 | Supercinnamaldehyde | 70351-51-8 | Supercinnamaldehyde is a potent activator of transient receptor potential ankyrin 1 (TRPA1) with EC50 of 0.8 μM. |
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V70147 | TAT-M2NX (tatM2NX) | 2126166-03-6 | TAT-M2NX (tatM2NX) is a TRPM2 inhibitor (antagonist) with specific neuro-protection activity in male mice. |
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