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    JNJ-17203212
    JNJ-17203212

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4502
    CAS #: 821768-06-3Purity ≥98%

    Description: JNJ-17203212 is a novel, potent, reversible, competitive and selective TRPV1 antagonist with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. JNJ-17203212 inhibits capsaicin- and H+-induced channel activation (pIC50 values are 6.32 and 7.23 respectively) and exhibits antitussive and analgesic activity in vivo.  JNJ-17203212, reduces sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity. These data indicate that TRPV1 is involved in the pathogenesis of visceral hypersensitivity and that JNJ-17203212 may be a potential therapeutic agent for functional bowel disorders characterized by abdominal hypersensitivity, such as irritable bowel syndrome.

    References 2010 Oct;32(8):557-64.


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    JNJ-17203212

    Name: JNJ-17203212
    CAS#: 821768-06-3
    Chemical Formula: C17H15F6N5O
    Exact Mass: 419.11808
    Molecular Weight: 419.32
    Elemental Analysis: C, 48.69; H, 3.61; F, 27.18; N, 16.70; O, 3.82
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: JNJ-17203212; JNJ 17203212; JNJ17203212.
    IUPAC/Chemical Name: 1-Piperazinecarboxamide, 4-(3-(trifluoromethyl)-2-pyridinyl)-N-(5-(trifluoromethyl)-2-pyridinyl)-
    InChi Key: JFRYYGVYCWYIDQ-UHFFFAOYSA-N
    InChi Code: InChI=1S/C17H15F6N5O/c18-16(19,20)11-3-4-13(25-10-11)26-15(29)28-8-6-27(7-9-28)14-12(17(21,22)23)2-1-5-24-14/h1-5,10H,6-9H2,(H,25,26,29)
    SMILES Code: O=C(N1CCN(C2=NC=CC=C2C(F)(F)F)CC1)NC3=NC=C(C(F)(F)F)C=C3


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