The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74823 | Metyrosine-13C9,15N,d7 | 1994331-23-5 | Metyrosine-13C9,15N,d7 is Metyrosine with 13C, 15N and deuterated labels. |
|
V73500 | Murraol (CM-c2) | 109741-38-0 | Murraol (CM-c2) is a coumarin extracted from the leaves of Madagascar cypress (Apiaceae). |
|
V74825 | N-Acetyl-2-carboxybenzenesulfonamide | 849067-18-1 | N-Acetyl-2-carboxybenzenesulfonamide is an orally bioactive COX-1 and COX-2 inhibitor (antagonist) with IC50 of 0.06 μM and 0.25 μM, respectively. |
|
V1072 | Nabumetone (BRL 14777) | 42924-53-8 | Nabumetone (formerly BRL-14777;BRL14777; Relafen, Relifex, Gambaran, Arthraxan), a non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor and a prodrug with potential anti-inflammatory activity. |
|
V1054 | Naproxen Sodium (RS-3650) | 26159-34-2 | Naproxen Sodium (formerly RS 3650; RS-3650; Naproxen natrium), an approved non-steroidal anti-inflammatory drug (NSAID), is a nonselective COX inhibitor for COX-1 and COX-2 with potential anti-inflammatory activity. |
|
V1039 | Nepafenac (AHR9434; AL6515; Nevanac) | 78281-72-8 | Nepafenac (formerly AHR9434;AL 6515;AL-6515;AHR-9434; Nevanac; Nevanac) is a potent non-steroidal anti-inflammatory drug (NSAID), and a prodrug of amfenac that acts as an inhibitor of COX-1 and COX-2 enzyme activity. |
|
V1064 | Niflumic acid | 4394-00-7 | Niflumic acid (Flunir, Donalgin,Niflactol, Niflugel, Nifluril) is a potent inhibitor of cyclooxygenase-2 (COX-2) enzyme with potential anti-inflammatory and analgesic activity. |
|
V1060 | Nimesulide (R805) | 51803-78-2 | Nimesulide (formerly R-805;R 805;R805), a non-steroidal anti-inflammatory drug (NSAID), is a potent and selective COX-2 inhibitor with analgesic and antipyretic properties. |
|
V74806 | Ocarocoxib | 215122-22-8 | Ocarocoxib, a potent COX-2 (cyclooxygenase-2) inhibitor, is a veterinary non-steroidal anti~inflammatory drug. |
|
V1065 | Oxaprozin (Oxaprozinum; Wy21743) | 21256-18-8 | Oxaprozin (Oxaprozinum, DL-8280,WY-21743; DR-3355, Hoe-280, ORF-28489, Ru-43280, Tarivid) is a potent nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. |
|
V74859 | Peonidin chloride (YGM-6 chloride) | 134-01-0 | Peonidin chloride is an O-methylated anthocyanin that, as a major plant pigment, gives flowers such as peonies their purple-red hue, hence their name, and also gives berries and vegetables their purple-red color. |
|
V1058 | Phenacetin (Acetophenetidin) | 62-44-2 | Phenacetin (also known as acetophenetidin) is a potent non-opioid analgesic agent without anti-inflammatory properties. |
|
V74810 | Phenacetin-13C (phenacetin-13C; phenacetin-13C) | 72156-72-0 | Phenacetin-13C is 13C (carbon 13)-labeled phenacetin. |
|
V74801 | Phenacetin-d5 (Acetophenetidin-d5) | 69323-74-6 | Phenacetin-d5 is the deuterium labelled form of Phenacetin. |
|
V73509 | Phenethyl ferulate | 71835-85-3 | Phenethyl ferulate is a major component of Qianghuo and exhibits inhibitory effect against cyclooxygenase (COX) and 5-lipoxygenase (5-LOX), with IC50s of 4.35 μM and 5.75 μM respectively. |
|
V74802 | Phenidone | 92-43-3 | Phenidone, an orally bioactive dual (bifunctional) inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), can improve paralysis in rats with experimental autoimmune encephalomyelitis. |
|
V74866 | Phenyl β-D-glucopyranoside (phenyl-β-D-glucopyranoside hydrate) | 1464-44-4 | Phenyl β-D-glucopyranoside has anticancer and anti-inflammatory activities. |
|
V74803 | Phenylbutazone(diphenyl-d10) | 1219794-69-0 | Phenylbutazone (diphenyl-d10) is the deuterated form of Phenylbutazone. |
|
V74854 | Pifoxime | 31224-92-7 | Pifoxime is a COX-1/2 inhibitor and a nonsteroidal anti-inflammatory agent (NSAID). |
|
V1055 | Piroxicam (CP-16171) | 36322-90-4 | Piroxicam (formerly BAXO; CP16171; CP-16171; Feldene; Pyroxycam; Roxicam), an approved non-steroidal anti-inflammatory drug (NSAID), is a potent and non-selective COX inhibitor with potential anti-inflammatory activity. |
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