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    Naproxen Sodium (RS-3650)
    Naproxen Sodium (RS-3650)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1054
    CAS #: 26159-34-2Purity ≥98%

    Description: Naproxen Sodium (formerly RS 3650; RS-3650; Naproxen natrium), an approved non-steroidal anti-inflammatory drug (NSAID), is a nonselective COX inhibitor for COX-1 and COX-2 with potential anti-inflammatory activity. It inhibits COX-1 and COX-2 with IC50s of 8.7 μM and 5.2 μM, respectively. 

    References: Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7; Br J Pharmacol. 2006 Jun;148(4):396-404. 

    Related CAS#: 22204-53-1 (free acid)

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    Molecular Weight (MW)252.24 
    CAS No.26159-34-2 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 3 mg/mL (11.9 mM) 
    Water: 50 mg/mL (198.2 mM)
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 2-Naphthaleneacetic acid, 6-methoxy-alpha-methyl-, sodium salt, (S)-


    InChi Code: InChI=1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

    SMILES Code: O=C([O-])[[email protected]@H](C)C1=CC=C2C=C(OC)C=CC2=C1.[Na+]

    SynonymsRS-3650; Sodium naproxen; RS 3650; RS3650; Naproxen natrium

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    In Vitro

    In vitro activity: Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50 of 2.2 μg/mL and 1.3 μg/mL, respectively. Naproxen decreases the in vitro LPS-induced PGE2 and TXB2 production in rats and humans with IC50 of 30.7 μM and 79.5 μM for PGE2 inhibition, 72.4 μM and 48.3 μM for TXB2 inhibition, respectively. Naproxen produces concentration-related inhibition of TXB2 production from human platelets and LPS-induced TXB2 production from human mononuclear cells with plC50 values (-log concentration inhibiting TXB2 by 50%) of 5.7 and 6.4, respectively, and exhibits slightly inhibitory selectivity for constitutive and induced COX-2 with IC50 COX-1/IC50 COX-2 of 6.3. Only high concentration of Naproxen can significantly induce apoptosis at 48 hours in HCA-7 colon cancer cells with IC50 of 1.45 mM.

    Kinase Assay: For the determination of COX-1 and COX-2 inhibition, bovine aortic endothelial cells (BAEC) are incubated for 30 minutes with Naproxen (0.1 ng/mL to 1 mg/mL), and cultured J774.2 macrophages are treated with endotoxin at 1 μg/mL for 12 hours to induce COX-2 followed by incubated for 30 minutes with Naproxen (0.1 ng/mL to 1 mg/mL), respectively. Arachidonic acid (30 μM) is then added, and the cells are incubated for a further 15 minutes at 37 °C. The medium is then removed, and radioimmunoassay is used to measure the formation of 6-keto-PGF1α, PGE2, thromboxane B2, or PGF2α for the assessment of IC50 for COX-1 and COX-2. 

    Cell Assay: Cells (Human colon cancer HCA-7 cell lines) are exposed to Naproxen for 24 and 48 hours, respectively. At the end of incubation, cells are harvested by trypsinization, stained with trypan blue solution (0.04% wt/vol) and counted in a Neubauer haemocytometer chamber for the determination of cell viability.

    In VivoAdministration of Naproxen reduces the LPS-induced PGE2 and TXB2 production in vivo in rats with IC50 values of 12.8 μM and 5.9 μM, respectively, which represents that Naproxen is a nonselective COX inhibitor with the log IC50 ratio (COX-2/COX-1) of 0.34. Naproxen displays IC50 of 27 μM for analgesia in a rat model with carrageenan-induced arthritis and IC50 of 40 μM for antipyretics in a yeast-induced fever rat model, while exhibits inhibition of PGE2 with IC50 of 13 μM and TXB2 with IC50 of 5 μM. 
    Animal modelMale Sprague-Dawley rats 
    Formulation & DosageDissolved in 0.9% NaCl; 2.5, 10 or 25 mg/kg; i.v. or i.p. injection 

    Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7; Br J Pharmacol. 2006 Jun;148(4):396-404.  

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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