The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V1049 | Ibuprofen Lysine | 57469-77-9 | Ibuprofen Lysine (Arflamin, Ibuprofen lysinate, NeoProfen, Saren), the pyridyl ester of ibuprofen, is ananti-inflammatory drug that belongs to thenon-steroidal anti-inflammatory drug (NSAIDs) class. |
|
V1041 | Indomethacin (Indometacin) | 53-86-1 | Indomethacin (Indometacin; Indocin) is a potent and non-selective COX1 and COX2 inhibitor of the nonsteroidal anti-inflammatory drug (NSAID) classwith an IC50 of 0.1 μg/mL and 5 μg/mL, respectively. |
|
V74819 | Indomethacin heptyl ester | 282728-47-6 | Indomethacin heptyl ester is a selective COX-2 inhibitor (antagonist) with IC50 of 0.04 μM and anti~inflammatory activity. |
|
V67782 | K-80001 | 242800-40-4 | K-80001 is a RXRα binding agent and COX-1/2 inhibitor, with IC50s of 82.9 μM, 3.4 μM, and 1.2 μM for RXRα, COX-1, and COX-2 respectively. |
|
V51911 | Kadsulignan N | 163564-58-7 | Kadsulignan N, a naturally occurring compound, has anti-HIV activity (EC50= 43.56 μM). |
|
V1053 | Ketoprofen (RP-19583) | 22071-15-4 | Ketoprofen (formerly RP 19583;RP-19583;Ketoprofen, Profenid, Orudis, Alrheumun, Capisten)is a potentnonsteroidal anti-inflammatory drugs (NSAID), acting as adual COX1/2 inhibitorwith potential anti-inflammatory activity. |
|
V1050 | Ketorolac (RS37619) | 74103-06-3 | Ketorolac(Toradol, Acular,RS 37619;RS37619; Sprix, Macril, Acuvail, Lixidol), an NSAID (non-steroidal anti-inflammatory drug), is a potent and non-selective COX inhibitor of COX-1 and COX-2 with potential anti-inflammatory activity. |
|
V74183 | LFS-1107 | 1799330-91-8 | LFS-1107 is a reversible CRM1 inhibitor (Kd: 12.5 pM). |
|
V74849 | LM-4108 (N-(2-Phenylethyl)-indomethacin amide) | 261766-32-9 | LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally bioactive COX-2 inhibitor (antagonist) with IC50 of 0.06 μM for purified human COX-2. |
|
V74863 | Longiferone B | 1639810-67-5 | Longiferone B is a carrot sesquiterpene that can be extracted from the rhizome of Boesenbergia longiflora. |
|
V1066 | Lornoxicam (Chlortenoxicam; Ro 13-9297; TS110) | 70374-39-9 | Lornoxicam (Chlortenoxicam; Xefo; Lornoxicamum; Xefocam; TS-110; Ro 13-9297; TS110), a non-steroidal anti-inflammatory drug (NSAID), is apotentCOX-1/COX-2 inhibitor with potential anti-inflammatory activity. |
|
V1068 | Lumiracoxib (CGS 35189; COX 189) | 220991-20-8 | Lumiracoxib (formerly CGS-35189;COX-189; trade name Prexige), a non-steroidal anti-inflammatory drug (NSAID),is a selective COX-2 enzyme inhibitor with potential anti-inflammatory activity. |
|
V1047 | Meclofenamate Sodium (Meclofenamic acid sodium) | 6385-02-0 | Meclofenamate Sodium (Meclonax; Meclomen;INF-4668; INF4668; CI 583; CI-583;Meclodium; Meclofenamic acid sodium) is a potentnonsteroidal anti-inflammatory drug (NSAID), acting as adual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively. |
|
V1073 | Mefenamic Acid (CI 473; CN-35355) | 61-68-7 | Mefenamic Acid (CI-473; CN-35355; CI 473; CN 35355;Mefenamic Acid; Ponstel; Parkemed; Coslan), a nonsteroidal anti-inflammatory drug (NSAID), is potent, nonselective,competitive inhibitor of the enzymes COX-1 and COX-2 with anti-inflammatory activity. |
|
V74811 | Mefenamic acid-13C6 (Mefenamic acid 13C6) | 1325559-19-0 | Mefenamic acid-13C6 is a 13C (carbon 13)-labeled Mefenamic acid. |
|
V74841 | Mefenamic Acid-d3 (Mefenamic Acid d3) | 1189707-81-0 | Mefenamic Acid-d3 is the deuterated form of Mefenamic acid. |
|
V74852 | Mefenamic acid-d4 (Mefenamic acid d4) | 1216745-79-7 | Mefenamic acid-d4 is the deuterated form of Mefenamic acid. |
|
V1044 | Meloxicam | 71125-38-7 | Meloxicam (Parocin; Movicox; Meloxicamum;Mobic; Mobicox; reumoxicam;Movalis; Uticox), an approved medication used to treat pain and inflammation in rheumatic arthritis and osteoarthritis,is a potent non-steroidal anti-inflammatory drug (NSAID)which acts as a selective COX inhibitor withIC50s of 0.49 µM and 36.6 µM for COX-2 and COX-1, respectively. |
|
V74821 | Methoxycoronarin D (Coronarin D Me ether) | 157528-81-9 | Methoxycoronarin D can be extracted from Hedychium coronarium J. |
|
V74836 | Methyl Salicylate-d4 (Wintergreen oil-d4) | 1219802-12-6 | Methyl Salicylate-d4 is the deuterium labelled form of Methyl Salicylate. |
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