The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1076 | Asaraldehyde (Asaronaldehyde) | 4460-86-0 | Asaraldehyde (also called Asaronaldehyde;2,4,5-trimethoxy-Benzaldehyde), a naturally occuring compound extracted from carrot (Daucus carotaL. |
|
V1062 | Aspirin (Acetylsalicylic Acid; ASA) | 50-78-2 | Aspirin (Acetylsalicylic acid; ASA; Acetylin; Claradin), a widely used analgesic and a salicylate analog, is a non-selectiveand covalent/irreversible inhibitor of COX1 and COX2 enzymes with a broad range of biological activities such as anti-inflammatory and pain relieving effects. |
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V73501 | Atractylochromene | 203443-33-8 | Atractylochromene is a potent dual (bifunctional) inhibitor of 5-LOX and COX-1 with IC50 of 0.6 and 3.3 μM respectively. |
|
V74858 | Axinelline A | 1593741-99-1 | Axinelline A is a potent COX inhibitor (antagonist) with IC50s of 2.22 μM and 8.89 μM for COX-2 and COX-1 respectively. |
|
V1048 | Bromfenac Sodium (AHR 10282R) | 91714-93-1 | Bromfenac Sodium (formerly AHR-10282R;AHR10282R;AHR-10282, AHR10282; trade names Prolensa,Bromday, Xibrom), an approved nonsteroidal anti-inflammatory drug (NSAID), is an orally bioavailable COX-1/2 inhibitor with anti-inflammatory activity. |
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V74837 | Buddlejasaponin IV | 139523-30-1 | Buddlejasaponin IV (BS-IV) has anti~inflammatory and cytotoxicities on cancer/tumor cells. |
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V1063 | Bufexamac (Bufexamic acid) | 2438-72-4 | Bufexamac (formerly also known as CP-1044-J-3; CP1044J3; Droxaryl; Parfenac; Bufexamic acid),a non-steroidal anti-inflammatory drug/NSAID, is a potentCOX enzyme inhibitor with potential anti-inflammatory activity. |
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V73510 | BW755C | 66000-40-6 | BW 755C is a 5-lipoxygenase (5-LO) inhibitor (antagonist) with IC50 of 5 μM. |
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V74828 | C2 Ceramide (d14:1/2:0) | 2097561-20-9 | C2 Ceramide (d14:1/2:0) is a composition indicated for the diagnosis of diseases associated with cyclooxygenase 2 (COX2) overexpression. |
|
V1074 | Carprofen | 53716-49-7 | Carprofen (Rimadyl; Ro-205720; C 5720; quellin; Novox; Imafen; Rovera), a nonsteroid anti-inflammatory drug (NSAID), isa potent and multi-targetFAAH/COXinhibitor with potential anti-inflammatory activity. |
|
V1038 | Celecoxib (SC 58635) | 169590-42-5 | Celecoxib (formerly SC58635; YM-177;SC-58635; YM 177;trade name Celebrex; Xilebao), ananti-inflammatory agent of the NSAID class,is a potent and selective COX-2 inhibitor of thenon-steroidal anti-inflammatory drug (NSAID) class with an IC50 of 40 nM in Sf9 cells. |
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V74843 | Celecoxib-d3 (SC 58635-d3) | 544686-18-2 | Celecoxib-d3 is the deuterium labelled form of celecoxib. |
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V74807 | Celecoxib-d7 (SC 58635-d7) | 544686-21-7 | Celecoxib-d7 is the deuterium labelled form of celecoxib. |
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V67675 | Chlorotrianisene-d9 (chloroprene diene d9) | 1276197-26-2 | Chlorotrianisene-d9 is the deuterated form of Chlorotrianisene. |
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V74868 | Clematomandshurica saponin B | 916649-91-7 | Clematomandshurica saponin B has a significant inhibitory activity against cyclooxygenase-2 (IC50=2.58 mM). |
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V74855 | COX-1/2-IN-2 | 2882832-86-0 | COX-1/2-IN-2 is a potent COX1/2 inhibitor. |
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V73755 | COX-2-IN-30 | 1160498-08-7 | COX-2-IN-30 is a benzene sulfonamide analogue and an orally bioactive COX/5-LOX dual (bifunctional) inhibitor (antagonist) with IC50 of 49 nM (COX) and 10.4 μM (5-LOX) respectively. |
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V74867 | COX-2-IN-32 | 2725863-08-9 | COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. |
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V74865 | COX-2-IN-34 | 2788578-71-0 | COX-2-IN-34 (compound 8a) is a selective, orally bioactive COX-2 inhibitor (antagonist) with no gastric ulcer toxicity and anti~inflammatory effects. |
|
V74860 | COX-2-IN-6 | 2756347-91-6 | COX-2-IN-6 (compound 10) is an orally bioactive, gut-restricted, and selective cyclooxygenase-2 (COX-2) inhibitor for the chemoprevention of colorectal cancer. |
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