The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V69218 | COX-2/PI3K-IN-2 | 2459938-28-2 | COX-2/PI3K-IN-2 (compound 5f) is a potent PI3K inhibitor (antagonist) with IC50 of 2.78 nM. |
|
V74856 | Daturaolone | 41498-80-0 | Daturaolone is a naturally occurring triterpenoid with anti~inflammatory and anti-nociceptive potential. |
|
V73737 | Dehydroglyasperin D | 517885-72-2 | DeHydroglyasperin D inhibits rat and human Aldose Reductase (AR) (IC50 62.4 μM and 176.2 μM, respectively). |
|
V74846 | Dehydroperilloxin | 263241-09-4 | Dehydroperilloxin is a natural compound extracted from the methylene chloride extract of the stems of Perilla frutescens var. |
|
V74826 | Dexketoprofen (trometamol) (dexketoprofen tromethamine salt) | 156604-79-4 | Dexketoprofen trometamol (Dexketoprofen tromethamine salt) is an orally bioactive, non-selective COX inhibitor. |
|
V29331 | Diclofenac diethylamine | 78213-16-8 | Diclofenac diethylamine is a potent nonsteroidal anti-inflammatory drug (NSAID), acting as a non-selective COX inhibitor with IC50 of 0.5 μg/ml and 0.5 μg/ml for COX-1 and -2 in intact cells, respectively, used to relieve pain and reduce swelling in flammation. |
|
V74809 | Diclofenac epolamine (Diclofenac epolamine; Diclofenac hydroxyethylpyrrolidine) | 119623-66-4 | Flector Patch (Diclofenac epolamine) is a nonsteroidal anti-inflammatory drug (NSAID) indicated for the relief of arthritis pain, acute pain, osteoarthritis, and more. |
|
V1051 | Diclofenac Sodium (GP 45840) | 15307-79-6 | Diclofenac Sodium (Abitren, Blesin, Delimon,Allvoran, Berifen, Delphimix, Voltaren, Voltarol;Assaren, Batafil,GP-45840) is a nonsteroidal anti-inflammatory drug (NSAID), acting as a non-selective COX inhibitor with potential anti-inflammatory activity. |
|
V74827 | Esculentic acid | 103974-74-9 | Esculentic Acid is a selective COX-2 inhibitor (antagonist) with anti-inflammatory effects. |
|
V1052 | Etodolac (AY-24236) | 41340-25-4 | Etodolac(AY-24236, Etodolic Acid, AY24,236, AY24236, Lodine, Ramodar, Ultradol) is a potent nonsteroidal anti-inflammatory drug (NSAID) and a non-selectiveCOX inhibitor with potential anti-inflammatory activity. |
|
V4391 | ETORICOXIB | 202409-33-4 | Etoricoxib (also known as MK-0663) is a non-steroidal anti-inflammatory drgu (NSAID) which acts as a selective and orally bioactiveCOX-2inhibitor, withIC50s of 1.1 μM and 116 μM for COX-2 and COX-1 in human whole blood. |
|
V74814 | Etoricoxib-d3 (MK-0663-d3; L-791456-d3) | 850896-71-8 | Etoricoxib-d3 is the deuterated form of Etoricoxib. |
|
V74808 | Firocoxib-d4 (Firocoxib-d4) | 1325700-11-5 | Firocoxib-d4 is the deuterium labelled form of Firocoxib. |
|
V1061 | Flunixin Meglumin | 42461-84-7 | Flunixin Meglumin (Banamine; Flumeglumine; Flunixin-S), a non-steroidal anti-inflammatory drug (NSAID), is a potent inhibitor of the enzyme COX-cyclooxygenase with analgesic, anti-inflammatory and antipyretic activities. |
|
V74845 | Flunixin-d3 (flunixin meglumine-d3) | 1015856-60-6 | Flunixin-d3 is the deuterium labelled form of Flunixin. |
|
V73225 | Hydrangenol | 480-47-7 | Hydrangenol is an orally bioavailable anti-photoaging compound. |
|
V1040 | Ibuprofen (Advil; Motrin; Brufen) | 15687-27-1 | Ibuprofen (Dolgesic; Advil, Motrin, Nurofen, Brufen among others), a potentanti-inflammatory drug of the NSAID class, is an inhibitor of COX-1 and COX-2 enzymes with IC50s of 13 μM and 370 μM, respectively. |
|
V74838 | Ibuprofen impurity 1 | 3585-47-5 | Ibuprofen impurity 1 is the impurity of Ibuprofen. |
|
V74817 | Ibuprofen Impurity F | 65322-85-2 | Ibuprofen Impurity F is the impurity of Ibuprofen. |
|
V74840 | Ibuprofen Impurity K | 43153-07-7 | Ibuprofen Impurity K is the impurity of Ibuprofen. |
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