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Description: Oxaprozin (Oxaprozinum, DL-8280, WY-21743; DR-3355, Hoe-280, ORF-28489, Ru-43280, Tarivid) is a potent nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is also an inhibitor of COX-1 and COX-2 enzymes with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin has been approved for use in the treatment of RA-rheumatoid arthritis, OA-osteoarthritis, dysmenorrhea, and to alleviate moderate pain. The anti-inflammatory activity of Oxaprozin is due to inhibition of COX-cylooxygenase in platelets, which results in the blockage of prostaglandin synthesis. Oxaprozin shows lower COX-2 selectivity implying higher COX-1 selectivity.
References: Curr Med Res Opin. 2004 Aug;20(8):1275-7.
Chemical Name: 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
InChi Key: GSDSWSVVBLHKDQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
SMILES: CC1COC2=C3N1C=C(C(O)=O)C(C3=CC(F)=C2N4CCN(C)CC4)=O
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
In vitro activity: Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain. Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin shows lower COX-2 selectivity implying higher COX-1 selectivity.
Curr Med Res Opin. 2004 Aug;20(8):1275-7.
Purity ≥ 98%
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