My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Oxaprozin (Oxaprozinum; Wy21743)
    Oxaprozin (Oxaprozinum; Wy21743)

    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1065
    CAS #: 21256-18-8Purity ≥98%

    Description: Oxaprozin (Oxaprozinum, DL-8280, WY-21743; DR-3355, Hoe-280, ORF-28489, Ru-43280, Tarivid) is a potent nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is also an inhibitor of COX-1 and COX-2 enzymes with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin has been approved for use in the treatment of RA-rheumatoid arthritis, OA-osteoarthritis, dysmenorrhea, and to alleviate moderate pain. The anti-inflammatory activity of Oxaprozin is due to inhibition of COX-cylooxygenase in platelets, which results in the blockage of prostaglandin synthesis. Oxaprozin shows lower COX-2 selectivity implying higher COX-1 selectivity.

    References: Curr Med Res Opin. 2004 Aug;20(8):1275-7.

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)293.32 
    CAS No.21256-18-8 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 59 mg/mL (201.1 mM)
    Water: <1 mg/mL
    Ethanol: 27 mg/mL (92.0 mM)
    Other info

    Chemical Name: 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid


    InChi Code: InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)


    SynonymsWY21743; Oxaprozin, Oxaprozinum, DL-8280, WY-21743; WY 21743; DR-3355, Hoe-280, ORF-28489, Ru-43280, Tarivid

    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      • V1
      • C2
      • V2
    In Vitro

    In vitro activity: Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain. Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin shows lower COX-2 selectivity implying higher COX-1 selectivity.

    In Vivo
    Animal model
    Formulation & Dosage

    Curr Med Res Opin. 2004 Aug;20(8):1275-7. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.


      Home Prev Next Last page / pices


      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      Do you confirm the receipt?