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    Oxaprozin (Oxaprozinum; Wy21743)
    Oxaprozin (Oxaprozinum; Wy21743)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1065
    CAS #: 21256-18-8Purity ≥98%

    Description: Oxaprozin (Oxaprozinum, DL-8280, WY-21743; DR-3355, Hoe-280, ORF-28489, Ru-43280, Tarivid) is a potent nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. It is also an inhibitor of COX-1 and COX-2 enzymes with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin has been approved for use in the treatment of RA-rheumatoid arthritis, OA-osteoarthritis, dysmenorrhea, and to alleviate moderate pain. The anti-inflammatory activity of Oxaprozin is due to inhibition of COX-cylooxygenase in platelets, which results in the blockage of prostaglandin synthesis. Oxaprozin shows lower COX-2 selectivity implying higher COX-1 selectivity.

    References: Curr Med Res Opin. 2004 Aug;20(8):1275-7.

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    Molecular Weight (MW)293.32 
    FormulaC18H15NO3 
    CAS No.21256-18-8 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 59 mg/mL (201.1 mM)
    Water: <1 mg/mL
    Ethanol: 27 mg/mL (92.0 mM)
    Other info

    Chemical Name: 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

    InChi Key: GSDSWSVVBLHKDQ-UHFFFAOYSA-N

    InChi Code: InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)

    SMILES: CC1COC2=C3N1C=C(C(O)=O)C(C3=CC(F)=C2N4CCN(C)CC4)=O

    SynonymsWY21743; Oxaprozin, Oxaprozinum, DL-8280, WY-21743; WY 21743; DR-3355, Hoe-280, ORF-28489, Ru-43280, Tarivid


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    In Vitro

    In vitro activity: Oxaprozin is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Oxaprozin is used to treat rheumatoid arthritis, osteoarthritis, dysmenorrhea, and to alleviate moderate pain. Anti-inflammatory effects of Oxaprozin are believed to be due to inhibition of cylooxygenase in platelets which leads to the blockage of prostaglandin synthesis. Antipyretic effects may be due to action on the hypothalamus, resulting in an increased peripheral blood flow, vasodilation, and subsequent heat dissipation. Oxaprozin shows lower COX-2 selectivity implying higher COX-1 selectivity.

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    References

    Curr Med Res Opin. 2004 Aug;20(8):1275-7. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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