The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74850 | Tolmetin | 26171-23-3 | Tolmetin is an orally bioactive and potent COX inhibitor (antagonist) with IC50s of 0.35 μM and 0.82 μM for human COX-1 and COX-2, respectively. |
|
V1067 | Triflusal (UR1501) | 322-79-2 | Triflusal (formerly UR1501; Disgren, Grendis, Aflen, Triflux),a platelet aggregation inhibitor and a salicylate analog, acts by irreversibly inhibiting the production of thromboxane-B2 in platelets via acetylating the enzyme COX-1/cycloxygenase-1. |
|
V1071 | Valdecoxib (SC65872) | 181695-72-7 | Valdecoxib (SC-65872; SC65872; SC 65872; Bextra), a nonsteroidal anti-inflammatory drug (NSAID), is a potent andselective inhibitor of COX-2 enzyme with potential anti-inflammatory activity. |
|
V74848 | Valeryl salicylate (Valeroyl salicylate) | 64206-54-8 | Valeryl salicylate is a potent and irreversible inhibitor of cyclooxygenase-1 (COX-1). |
|
V74820 | Withangulatin A | 120824-03-5 | Withangulatin A is a selective cyclooxygenase 2 (COX-2) inhibitor. |
|
V1046 | Xanthohumol | 6754-58-1 | Xanthohumol, a naturally occuring prenylated chalcone compound isolated from hops (the female inflorescences of Humulus lupulus), is an inhibitor of COX-1 and COX-2 enzymatic activity and shows chemopreventive effects as well as anti-cancer and anti-angiogenic activities. |
|
V71983 | XO/COX/LOX-IN-1 | 2831329-35-0 | XO/COX/LOX-IN-1 (compound 7i) is a potent xanthine oxidase/cyclooxygenase/lipoxygenase XO/COX/LOX inhibitor. |
|
V1069 | Zaltoprofen (CN100) | 74711-43-6 | Zaltoprofen (CN 100; CN-100; CN100), a nonsteroidal anti-inflammatory drug (NSAID), is apotentinhibitor of COX-1 and COX-2 enzymeswith potential anti-inflammatory activity. |
|
V74834 | γ-Tocopherol-d4 (γ-Tocopherol d4) | 1329652-13-2 | γ-Tocopherol-d4 is the deuterated form of γ-Tocopherol. |
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