The enzyme cyclooxygenase (COX), also referred to as prostaglandin-endoperoxide synthase (PTGS), is in charge of producing the vital biological mediators known as prostanoids, such as prostaglandins, prostacyclin, and thromboxane. Pain and inflammation symptoms can be reduced by pharmacologically inhibiting COX. The general public has had access to cyclooxygenase activity-inhibiting medications for about 100 years, including aspirin. The two cyclooxygenase isoforms, COX-1 and COX-2, have been identified. The COX-1 enzyme is frequently produced constitutively (i.e., in the gastric mucosa), whereas the COX-2 enzyme is induced (i.e., at sites of inflammation). Aspirin and ibuprofen are examples of NSAIDs that work by inhibiting COX to produce their desired effects. The non-steroidal anti-inflammatory drugs (NSAIDs) are the primary COX inhibitors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74822 | Piroxicam cinnamate (Cinnoxicam; SPA-S-510; Sinartol) | 87234-24-0 | Piroxicam cinnamate (Cinnoxicam) is a cyclooxygenase (COX) inhibitor (antagonist) with anti-inflammatory activity. |
|
V74853 | Plantanone B (Kaempferol 3-O-rhamnosylgentiobioside) | 55780-30-8 | Plantanone B is a moderate antioxidant with IC50 of 169.8±5.2 μM. |
|
V73940 | PPOH | 206052-01-9 | PPOH, a fatty acid analogue, is a selective cyclooxygenase (COX) inhibitor that can suppress arachidonic acid cyclooxygenase activity in renal cortical microsomes. |
|
V1056 | Pranoprofen (Pyranoprofen) | 52549-17-4 | Pranoprofen (also known as Pyranoprofen), a potent and approved non-steroidal anti-inflammatory drugs (NSAIDs), is a COX inhibitor that has been used as an anti-inflammatory drug in ophthalmology. |
|
V74842 | Propyphenazone-d3 (Propyphenazone-d3) | 162935-29-7 | Propyphenazone-d3 is the deuterium labelled form of Propyphenazone. |
|
V74805 | Regaloside B (regaloside B) | 114420-67-6 | Regaloside B is a phenylpropanoid extracted from Lilium longiflorum. |
|
V75116 | Rehmapicrogenin (rehmapicrogenin) | 135447-39-1 | Rehmapicrogenin can be extracted from the roots of Rehmannia glutinosa and displays potent anti-inflammatory effects by inhibiting iNOS, COX-2 and IL-6. |
|
V1045 | Rofecoxib (MK 966) | 162011-90-7 | Rofecoxib (formerly MK-0966; MK0966; MK-966; MK966; Vioxx; Ceoxx; Ceeoxx.), an NSAID drug, is a potent and selective COX-2 inhibitor with potential anti-inflammatory activity. |
|
V74813 | Sinapyl alcohol | 537-33-7 | Sinapyl alcohol is an orally bioactive anti-inflammatory and anti-injury agent. |
|
V60122 | Sphondin | 483-66-9 | Sphondin has an inhibitory activity against IL-1β-induced increases in COX-2 protein and PGE2 release levels in A549 cells. |
|
V1042 | Sulindac (MK-231) | 38194-50-2 | Sulindac(Aflodac; Algocetil; MK231; MK 231;MK-231), belonging to the arylalkanoic acid class of non-steroidal antiinflammatory drugs (NSAIDs), isa non-steroidal COX inhibitor, which potently inhibits prostaglandin synthesis. |
|
V1077 | Suprofen (TN-762) | 40828-46-4 | Suprofen(R25061;TN762;R-25061;TN-762;Suprofen; Suprofenum; Profenal), a nonsteroid anti-inflammatory drug (NSAID), is a potent and nonselective dual inhibitor of COX-1/COX-2 enzymeswith potential anti-inflammatory and antipyretic activity. |
|
V74804 | Tazofelone (LY 213829) | 107902-67-0 | Tazofelone (LY 213829) is a cyclooxygenase-II (COX-II) inhibitor. |
|
V73505 | Tebufelone (NE-11740) | 112018-00-5 | Tebufelone (NE-11740) is a nonsteroidal anti-inflammatory agent (NSAID) and a selective dual COX-2/5-lipoxygenase inhibitor. |
|
V74815 | Tenidap-d3 (CP-66248-d3) | 142741-60-4 | Tenidap-d3 is the deuterium labelled form of Tenidap. |
|
V74851 | Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) | 1011244-72-6 | Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor (antagonist) with IC50 of 30 µM and low activity against COX-2 (IC50>100 µM). |
|
V60123 | Tetrahydrocoptisine (Stylopine) | 4312-32-7 | (±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound extracted from plant tubers of the genus Corydalis. |
|
V74847 | Tinoridine (Y-3642) | 24237-54-5 | Tinoridine (Y-3642) is an orally bioactive non-steroidal anti-inflammatory agent with potent antioxidant capacity and free radical scavenging activity. |
|
V1059 | Tolfenamic Acid (GEA 6414) | 13710-19-5 | Tolfenamic Acid (formerly GEA 6414;GEA6414;GEA-6414;Clotam), a non-steroidal anti-inflammatory drugs (NSAIDs), is a potent and selective COX-2 inhibitor with potential anti-inflammatory activity. |
|
V74824 | Tolfenamic acid-d4 (Tolfenamic acid d4) | 1246820-82-5 | Tolfenamic acid-d4 is the deuterated form of Tolfenamic Acid. |
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