5-HT receptors (Serotonin receptors) are a group of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems.5-HT1, 5-HT2, 5-HT3, 5-HT4, 5-HT5, 5-HT6, and 5-HT7 are the types. Both excitatory and inhibitory neurotransmission is mediated by them. The neurotransmitter serotonin, which serves as their inherently ligand, stimulates the serotonin receptors. Numerous neurotransmitters and hormones are released in response to stimulation of the serotonin receptors. Numerous biological and neurological functions, including aggression, anxiety, appetite, cognition, learning, memory, mood, nausea, sleep, and thermoregulation, are influenced by serotonin receptors. Many antidepressants, antipsychotics, anorectics, antiemetics, gastroprokinetic agents, antimigraine agents, hallucinogens, and entactogens are among the pharmaceuticals that target the serotonin receptors.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V71139 | U92016A hydrochloride | 149654-41-1 | U92016A HCl is a metabolically stable, orally bioactive 5-HT1A receptor agonist/activator with extremely high intrinsic activity. |
|
V71193 | UCSF686 | 2248852-19-7 | UCSF686 is a probe to study the function of 5-HT5AR. |
|
V1025 | Urapidil HCl | 64887-14-5 | Urapidil HCl, the hydrochloride salt of uradipil which is a sympatholytic antihypertensive drug, is potent α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. |
|
V71189 | Urapidil-d3 (Urapidil d3) | 1398066-08-4 | Urapidil-d3 is the deuterium labelled form of Urapidil. |
|
V71164 | Usmarapride (SUVN-D4010) | 1428862-33-2 | Usmarapride (SUVN-D4010) is a specific, orally bioactive and BBB (blood-brain barrier) permeable (penetrable) 5-HT4 receptor partial agonist (EC50=nM). |
|
V1024 | Venlafaxine HCl (Wy 45030 HCl) | 99300-78-4 | Venlafaxine (Wy45030; Wy-45030; Effexor, Effexor XR, Lanvexin, Viepax, and Trevilor) is an arylalkanolamine-based antidepressant that has been approved for use. |
|
V32437 | Vilazodone (EMD 68843) | 163521-12-8 | Vilazodone (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. |
|
V0972 | Vilazodone HCl (EMD 68843; SB659746A) | 163521-08-2 | Vilazodone HCl (SB659746A; SB659746-A; EMD-68843; EMD68843; Viibryd), the hydrochloride salt of Vilazodone, is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of 5-HT1A receptors with anti-depressive effects. |
|
V28028 | Volinanserin | 139290-65-6 | Volinanserin (MDL-100907; M-100907) is a highly selective 5-HT2A receptor antagonist with antipsychotic activity and thus has the potential for treatment of schizophrenia. |
|
V71229 | Volinanserin-d4 hydrochloride (MDL100907-d4 hydrochloride; M 100907-d4 hydrochloride) | 1217617-73-6 | Volinanserin-d4 ( HCl) is the deuterated form of Volinanserin hydrochlorid. |
|
V4425 | Vortioxetine (AA21004) | 508233-74-7 | Vortioxetine (Lu-AA21004; Lu-AA-21004; Trintellix and Brintellix) is an approved anti-depressant drug acting as an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator. |
|
V0970 | Vortioxetine (Lu AA21004) HBr | 960203-27-4 | Vortioxetine HBr (formerly AA21004, Lu-AA21004, AA21004; Lu AA21004), the hydrobromide salt of Vortioxetine which is a marketed and atypical antidepressant, is an orally bioactive and multimodal serotonergic agent with potential anti-depressive activity. |
|
V2618 | Vortioxetine lactate | 1253056-29-9 | Vortioxetine lactate (formerly Lu-AA21004 lactate; Trintellix; Brintellix) is the lactate salt of Vortioxetine, whichis an atypical antidepressant which was approved in 2013 by the FDA for the treatment of major depressive disorder (MDD) in adults. |
|
V1026 | VUF 10166 | 155584-74-0 | VUF10166 (VUF-10166; VUF 10166) is a novel, potent and competitive antagonist against serotonin 5-HT3A receptor with important biological activity. |
|
V71159 | WAY 629 hydrochloride | 57756-44-2 | WAY 629 HCl is a potent and specific 5-HT2C agonist/activator with EC50s of 426 and 260000 nM for 5-HT2C and 5-HT2A respectively. |
|
V71128 | WAY-100135 dihydrochloride | 149055-79-8 | WAY-100135 di-HCl is a selective presynaptic and postsynaptic 5-HT1A receptor antagonist (inhibitor) with IC50 of 34 nM for rat hippocampal 5-HT1A receptors. |
|
V0996 | WAY-100635 Maleate | 1092679-51-0 | WAY-100635 maleate (WAY 100635; WAY100635), the maleate salt of WAY-100635, is a novel, potent and selective antagonist of serotonin 5-HT1A receptor with important biological activity. |
|
V7746 | WAY-181187 (SAX-187) | 554403-49-5 | WAY-181187 (SAX187) is a novel, potent and selective 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. |
|
V71171 | WAY-181187 hydrochloride (SAX-187 hydrochloride) | 554403-08-6 | WAY-181187 (SAX-187) HCl is a potent and specific 5-HT6 receptor agonist/activator with a Ki of 2.2 nM and EC50 of 6.6 nM. |
|
V28384 | YL-0919 | 1339058-04-6 | YL-0919 is a novel, potent and orally bioactive antidepressant acting as 5-HT1A receptor agonist (Ki=0.19 nM) and selective serotonin reuptake inhibitor. |
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
