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    VUF 10166
    VUF 10166

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1026
    CAS #: 155584-74-0Purity ≥98%

    Description: VUF10166 (VUF-10166; VUF 10166) is a novel, potent and competitive antagonist against serotonin 5-HT3A receptor with important biological activity. It inhibits 5-HT3A with a Ki of 0.04 nM.

    References: J Pharmacol Exp Ther. 2012 May;341(2):350-9.

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    Molecular Weight (MW)262.74 
    FormulaC13H15ClN4 
    CAS No.155584-74-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 21 mg/mL (79.9 mM) 
    Water: <1 mg/mL
    Ethanol: 61 mg/mL (232.2 mM) 
    SMILESCN1CCN(CC1)C2=NC3=CC=CC=C3N=C2Cl
    SynonymsVUF 10166; VUF-10166; VUF10166; 


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    In Vitro

    In vitro activity: VUF10166 shows low activity to 5-HT3AB receptor with Ki of 22 nM. VUF10166 may be used to can distinguish between 5-HT3A and 5-HT3AB receptors. VUF10166 has no activity to α7 nACh receptor. VUF10166 also acts as a partial agonist at 5-HT3A receptors with EC50 of 5.2 μM, which shows that VUF10166 is unlikely to bind in the receptor pore.

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    References

    J Pharmacol Exp Ther. 2012 May;341(2):350-9. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     
    VUF 10166
    Inhibition of 5-HT3 receptor responses by VUF10166. J Pharmacol Exp Ther. 2012 May;341(2):350-9. 
     
    VUF 10166
    The effects of 6′ channel substitutions on VUF10166 properties. J Pharmacol Exp Ther. 2012 May;341(2):350-9.
     
    VUF 10166
    The effects of 5-HT3B subunit mutations on VUF10166 inhibition. J Pharmacol Exp Ther. 2012 May;341(2):350-9.


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