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    Urapidil HCl
    Urapidil HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1025
    CAS #: 64887-14-5Purity ≥98%

    Description: Urapidil HCl, the hydrochloride salt of uradipil which is a sympatholytic antihypertensive drug, is potent α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Urapidil is currently not approved by the U.S. FDA, but it is available in Europe. Union 

    References: Br J Pharmacol. 1991 Apr; 102(4): 998–1002.

    Related CAS: 34661-75-1 (free base)

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    Molecular Weight (MW)423.94 
    FormulaC20H29N5O3.HCl 
    CAS No.64887-14-5 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 24 mg/mL (56.61 mM) 
    Water: 85 mg/mL (200.5 mM) 
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione monohydrochloride

    InChi Key: KTMLZVUAXJERAT-UHFFFAOYSA-N

    InChi Code: InChI=1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H

    SMILES Code: COC1=CC=CC=C1N2CCN(CCCNC3=CC(N(C)C(N3C)=O)=O)CC2.Cl

    SynonymsUrapidil hydrochloride


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    In Vitro

    In vitro activity: Urapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system. Several studies have suggested that oral urapidil is effective and well tolerated when used as second-line therapy in patients with BP inadequately controlled with other agents. Urapidil has also been shown to improve glucose and lipid metabolism in hypertensive patients with concomitant diabetes and/or hyperlipidemia.

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    References

    Naunyn Schmiedebergs Arch Pharmacol. 1987 Dec;336(6):597-601; Adv Ther. 2010 Jul;27(7):426-43. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     
    Urapidil HCl
    Effects of intravenous urapidil on (A) SBP, (B) DBP and (C) HR within 7 days of treatment, as compared with nitroglycerin, in elderly patients with hypertension and acute decompensated heart failure.  Exp Ther Med. 2016 Jul; 12(1): 115–122.
     
    Urapidil HCl
    Effects of intravenous urapidil on the serum level of NT-proBNP within 7 days of treatment, as compared with nitroglycerin, in elderly patients with hypertension and acute decompensated heart failure. Exp Ther Med. 2016 Jul; 12(1): 115–122.
     
    Urapidil HCl
    Effects of intravenous urapidil on the (A) LVEF and (B) LVEDV within 7 days of treatment, as compared with nitroglycerin, in elderly patients with hypertension and acute decompensated heart failure. Exp Ther Med. 2016 Jul; 12(1): 115–122.


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