My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Urapidil HCl
    Urapidil HCl

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1025
    CAS #: 64887-14-5Purity ≥98%

    Description: Urapidil HCl, the hydrochloride salt of uradipil which is a sympatholytic antihypertensive drug, is potent α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Urapidil is currently not approved by the U.S. FDA, but it is available in Europe. Union 

    References: Br J Pharmacol. 1991 Apr; 102(4): 998–1002.

    Related CAS: 34661-75-1 (free base)

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)423.94 
    FormulaC20H29N5O3.HCl 
    CAS No.64887-14-5 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 24 mg/mL (56.61 mM) 
    Water: 85 mg/mL (200.5 mM) 
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione monohydrochloride

    InChi Key: KTMLZVUAXJERAT-UHFFFAOYSA-N

    InChi Code: InChI=1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5,7-8,15,21H,6,9-14H2,1-3H3;1H

    SMILES Code: COC1=CC=CC=C1N2CCN(CCCNC3=CC(N(C)C(N3C)=O)=O)CC2.Cl

    SynonymsUrapidil hydrochloride


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2
    In Vitro

    In vitro activity: Urapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system. Several studies have suggested that oral urapidil is effective and well tolerated when used as second-line therapy in patients with BP inadequately controlled with other agents. Urapidil has also been shown to improve glucose and lipid metabolism in hypertensive patients with concomitant diabetes and/or hyperlipidemia.

    In Vivo
    Animal model
    Formulation & Dosage
    References

    Naunyn Schmiedebergs Arch Pharmacol. 1987 Dec;336(6):597-601; Adv Ther. 2010 Jul;27(7):426-43. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     
    Urapidil HCl
    Effects of intravenous urapidil on (A) SBP, (B) DBP and (C) HR within 7 days of treatment, as compared with nitroglycerin, in elderly patients with hypertension and acute decompensated heart failure.  Exp Ther Med. 2016 Jul; 12(1): 115–122.
     
    Urapidil HCl
    Effects of intravenous urapidil on the serum level of NT-proBNP within 7 days of treatment, as compared with nitroglycerin, in elderly patients with hypertension and acute decompensated heart failure. Exp Ther Med. 2016 Jul; 12(1): 115–122.
     
    Urapidil HCl
    Effects of intravenous urapidil on the (A) LVEF and (B) LVEDV within 7 days of treatment, as compared with nitroglycerin, in elderly patients with hypertension and acute decompensated heart failure. Exp Ther Med. 2016 Jul; 12(1): 115–122.


    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?