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    Ozagrel HCl (OKY046 HCl; KCT0809; Cataclot)
    Ozagrel HCl (OKY046 HCl; KCT0809; Cataclot)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0817
    CAS #: 78712-43-3Purity ≥98%

    Description: Ozagrel HCl (OKY-046 HCl; KCT 0809; Cataclot; Xanbo; OKY046 HCl), the hydrochloride salt of the antiplatelet drug Ozagrel, is a selective inhibitor of thromboxane A(2) (TXA(2)) synthetase (IC50 = 11 nM) with potential use for for the improving postoperative cerebrovascular contraction and accompanying cerebral ischaemia. Ozagrel prevents oleic acid (OA) induced thromboxane A(2) generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 andinterleukin-8 mRNA expression in the whole lung of guinea pigs.

    References: J Pharmacol Sci. 2009 Oct;111(2):211-5; Pharmacology. 1999 Nov;59(5):257-65.

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    Molecular Weight (MW)264.71
    FormulaC13H12N2O2.HCl
    CAS No.78712-43-3
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 53 mg/mL (200.2 mM)
    Water: 53 mg/mL (200.2 mM)
    Ethanol: 6 mg/mL (22.7 mM)
    Solubility (In vivo(E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)acrylic acid hydrochloride
    SynonymsOKY-046 HCl; KCT 0809; Cataclot; Xanbo; OKY046 HCl; Ozagrel hydrochloride, Ozagrel HCl; OKY 046 HCl; Ozagrel; KCT-0809; KCT0809; Ozagrel free acid


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    In Vitro

    In vitro activity: Ozagrel(OKY-046) is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor. Ozagrel was selected as the best compound of highly selective inhibitors of TXA2 synthase. The inhibition of TXA2 synthase by ozagrel was more effective on human and rabbit enzymes than those of other species. Ozagrel increased 6-keto-PGF1 alpha, one of stable metabolites of PGI2, in various isolated cells and tissues perhaps via accumulated PG endoperoxides resulted by the inhibition of TXA2 synthase

    In Vivo Ozagrel prevents oleic acid (OA) induced thromboxane A(2) generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 andinterleukin-8 mRNA expression in the whole lung of guinea pigs. Ozagrel (3 mg/kg) decreases both the area and volume of the cortical infarction after ischemia-reperfusion of the middle cerebral artery in rat. Ozagrel also has suppressive effects on the neurologic deficits in the microthrombosis rat model. Ozagrel improves the reduced spontaneously locomotor activity and the obstruction of motor coordination in the conscious cerebral ischemia-reperfusion mouse model. Ozagrel suppresses the decrease in specific gravity of the brain tissue induced by the occlusion-reperfusion in the conscious cerebral ischemia-reperfusion SHR model, and recovers the postischemic decrease in cortical PO(2) after middle cerebral artery occlusion-reperfusion in cats. Ozagrel also increases the level of 6-keto-PGF(1alpha), a metabolite of prostaglandin I(2) (PGI(2)), in the brain tissue after cerebral ischemia-reperfusion, and the administration of PGI(2) improves the reduced spontaneous locomotor activity in the conscious cerebral ischemia-reperfusion mouse model. Ozagrel administered intravenously 30 min before oleic acid injection prevents the decrease in Pao(2) and pulmonary vascular hyper-permeability in guinea-pigs. Ozagrel also prevents increases in lactate dehydrogenase activity, a measure of lung cell injury, TXB(2) and its weight ratio to 6-keto prostaglandin F(1alpha) in bronchoalveolar lavage fluid in guinea-pigs.
    Animal modelRats
    Formulation & Dosage3 mg/kg
    References

    J Pharmacol Sci. 2009 Oct;111(2):211-5; Pharmacology. 1999 Nov;59(5):257-65.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Ozagrel HCl


    Effects of ozagrel on serum ALT level and survival rate in APAP-induced liver injury. BMC Gastroenterol. 2013; 13: 21.
     

    Ozagrel HCl


    Effects of ozagrel on hepatic cell death-related markers in liver induced by APAP injection. BMC Gastroenterol. 2013; 13: 21.
     

    Ozagrel HCl


    Effects of ozagrel on hepatic GSH depletion induced by APAP and CYP 2E1 level. BMC Gastroenterol. 2013; 13: 21.


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