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    Sodium Danshensu
    Sodium Danshensu

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0822
    CAS #: 67920-52-9Purity ≥98%

    Description: Sodium Danshensu (Danshensu Sodium), the sodium salt of danshensu, is a novel, potent, naturally occuring phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza with various biological activity (e.g, antioxidant, anti-inflammatory). Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge. Danshensu is an efficient radical scavenger and antioxidant which exhibits higher scavenging activities against free hydroxyl radicals, superoxide anion radicals. 

    References: Food Chem Toxicol. 2008 Jan;46(1):73-81; Toxicol Mech Methods. 2010 Oct;20(8):510-4.

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    Molecular Weight (MW)220.15
    FormulaC9H9O5.Na
    CAS No.67920-52-9
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 7 mg/mL (31.8 mM)          
    Water: 2 mg/mL (9.1 mM)
    Ethanol: <1 mg/mL
    Solubility (In vivo)

    Chemical Name: α,3,4-trihydroxy-benzenepropanoic acid, monosodium salt

    InChi Key: ZMMKVDBZTXUHFO-UHFFFAOYSA-M

    InChi Code: InChI=1S/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1

    SMILES Code: OC1=C(O)C=CC(CC(O)C([O-])=O)=C1.[Na+]           

    Synonyms

    Danshensu sodium; Sodium Danshensu; (±)-DanShenSu sodium salt


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    In Vitro

    In vitro activity: Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge. Danshensu is an efficient radical scavenger and antioxidant which exhibits higher scavenging activities against free hydroxyl radicals (HO()), superoxide anion radicals (O(2)(-)), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and 2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals than vitamin C. Sodium danshensu shows a biphasic effects on vessel tension. In phenylephrine-precontracted thoracic arteries with or without endothelium, low concentration (0.1-0.3 g/L) of sodium danshensu produces a weak contraction, while high concentrations (1-3 g/L) produces a pronounced vasodilator after a transient vasocontraction. Pre-incubation with sodium danshensu could inhibit vessel contraction induced by phenylephrine and potassium chloride in a concentration-dependent way. Sodium danshensu also inhibits phenylephrine- and CaCl2-induced vasoconstriction in Ca(2+)-free medium.


    Cell Assay: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells

    In VivoThoracic aortae from normal rats were isolated and equilibrated in organ bath with Krebs-Henseleit buffer and ring tension was recorded. Effects of sodium danshensu on basal tonus of the vessel and its effects on vessel contraction and relaxation with or without endothelium were observed. In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammatio
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    References

    Food Chem Toxicol. 2008 Jan;46(1):73-81; Acta Pharmacol Sin. 2010 Apr;31(4):421-8; Toxicol Mech Methods. 2010 Oct;20(8):510-4.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Sodium Danshensu


    Effects of sodium danshensu on KCl-induced contractile response in endothelium-denuded rat aortic rings. Acta Pharmacol Sin. 2010 Apr;31(4):421-8. 
     

    Sodium Danshensu


    Effect of sodium danshensu on basal tonus in normal Krebs-Henseleit buffer (A) and in Ca2+-free Krebs-Henseleit buffer containing 1 mmol/L ethyleneglycoltetraacetic acid (EGTA) (B). Acta Pharmacol Sin. 2010 Apr;31(4):421-8.
     

    Sodium Danshensu


    Effects of sodium danshensu on phenylephrine-induced contractile response in endothelium-denuded rat aortic rings. Acta Pharmacol Sin. 2010 Apr;31(4):421-8. 


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