Sodium Danshensu

Alias:
Cat No.:V0822 Purity: ≥98%
Sodium Danshensu (Danshensu Sodium), the sodium saltof danshensu, is a novel, potent,naturally occuring phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza with various biological activity (e.
Sodium Danshensu Chemical Structure CAS No.: 67920-52-9
Product category: P450 (e.g. CYP)
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
25mg
50mg
100mg
250mg
500mg
Other Sizes

Other Forms of Sodium Danshensu:

  • Danshensu
  • (Rac)-Salvianic acid A ((Rac)-Danshensu; (Rac)-Danshensu)
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Sodium Danshensu (Danshensu Sodium), the sodium salt of danshensu, is a novel, potent, naturally occuring phenolic acid of caffeic acid derivatives isolated from Salvia miltiorrhiza with various biological activity (e.g, antioxidant, anti-inflammatory). Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge. Danshensu is an efficient radical scavenger and antioxidant which exhibits higher scavenging activities against free hydroxyl radicals, superoxide anion radicals.

Biological Activity I Assay Protocols (From Reference)
ln Vitro

In vitro activity: Sodium Danshensu is a mono sodium of danshensu which is a compound isolated from Salvia miltiorrhiza Bge. Danshensu is an efficient radical scavenger and antioxidant which exhibits higher scavenging activities against free hydroxyl radicals (HO()), superoxide anion radicals (O(2)(-)), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals and 2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radicals than vitamin C. Sodium danshensu shows a biphasic effects on vessel tension. In phenylephrine-precontracted thoracic arteries with or without endothelium, low concentration (0.1-0.3 g/L) of sodium danshensu produces a weak contraction, while high concentrations (1-3 g/L) produces a pronounced vasodilator after a transient vasocontraction. Pre-incubation with sodium danshensu could inhibit vessel contraction induced by phenylephrine and potassium chloride in a concentration-dependent way. Sodium danshensu also inhibits phenylephrine- and CaCl2-induced vasoconstriction in Ca(2+)-free medium.


Cell Assay: Sodium danshensu showed a biphasic effects on vessel tension. While low dosage of sodium danshensu produced small contraction possibly through transient enhancement of Ca2+ influx, high dosage produced significant vasodilation mainly through promoting the opening of non-selective K+ channels and small-conductance calcium-sensitive K+ channels in the vascular smooth muscle cells

ln Vivo
Thoracic aortae from normal rats were isolated and equilibrated in organ bath with Krebs-Henseleit buffer and ring tension was recorded. Effects of sodium danshensu on basal tonus of the vessel and its effects on vessel contraction and relaxation with or without endothelium were observed. In vivo: Danshensu did not change the expression of AGEs but partly blocked the increased expression of RAGE in the hippocampus of diabetic mice. Danshensu could ameliorate the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammatio
Animal Protocol

Rats
References
Food Chem Toxicol.2008 Jan;46(1):73-81;Toxicol Mech Methods.2010 Oct;20(8):510-4.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C9H9O5.NA
Molecular Weight
220.15
CAS #
67920-52-9
SMILES
[Na+].O([H])C([H])(C(=O)[O-])C([H])([H])C1C([H])=C([H])C(=C(C=1[H])O[H])O[H]
Synonyms

Danshensu sodium;Sodium Danshensu; (±)-DanShenSu sodium salt

Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 7 mg/mL (31.8 mM)
Water: 2 mg/mL (9.1 mM)
Ethanol:<1 mg/mL
Solubility (In Vivo)

Chemical Name: α,3,4-trihydroxy-benzenepropanoic acid, monosodium salt

InChi Key: ZMMKVDBZTXUHFO-UHFFFAOYSA-M

InChi Code: InChI=1S/C9H10O5.Na/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;/h1-3,8,10-12H,4H2,(H,13,14);/q;+1/p-1

SMILES Code: OC1=C(O)C=CC(CC(O)C([O-])=O)=C1.[Na+]

 (Please use freshly prepared in vivo formulations for optimal results.)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 4.5424 mL 22.7118 mL 45.4236 mL
5 mM 0.9085 mL 4.5424 mL 9.0847 mL
10 mM 0.4542 mL 2.2712 mL 4.5424 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

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An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?
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  • The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
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  • The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box
g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
Instructions to calculate molar mass (molecular weight) of a chemical compound:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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  • Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
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Reconstitution Calculator allows you to calculate the volume of solvent required to reconstitute your vial.

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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

Biological Data
  • Sodium Danshensu


    Effects of sodium danshensu on KCl-induced contractile response in endothelium-denuded rat aortic rings.Acta Pharmacol Sin.2010 Apr;31(4):421-8.
  • Sodium Danshensu


    Effect of sodium danshensu on basal tonus in normal Krebs-Henseleit buffer (A) and in Ca2+-free Krebs-Henseleit buffer containing 1 mmol/L ethyleneglycoltetraacetic acid (EGTA) (B).Acta Pharmacol Sin.2010 Apr;31(4):421-8.
  • Sodium Danshensu


    Effects of sodium danshensu on phenylephrine-induced contractile response in endothelium-denuded rat aortic rings.Acta Pharmacol Sin.2010 Apr;31(4):421-8.
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