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    Naringenin
    Naringenin

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0812
    CAS #: 480-41-1Purity ≥98%

    Description: Naringenin (S-Dihydrogenistein; Salipurol; NSC 11855; NSC-11855; NSC11855) is a naturally occuring flavanone extracted from plant food (e.g. grapefruit) with various biological activity such as anti-inflammatory, antioxidant, carbohydrate metabolism promoter, free radical scavenger, and immune system modulator.  

    References: JCarcinogenesis. 1990 Dec;11(12):2275-9; Diabetes Obes Metab. 2008 Nov;10(11):1097-104.

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    Molecular Weight (MW)272.25
    FormulaC15H12O5
    CAS No.480-41-1
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 54 mg/mL (198.3 mM)
    Water: <1 mg/mL
    Ethanol: 5 mg/mL (18.4 mM)
    Solubility (In vivo)

    Chemical Name: (S)-5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one

    InChi Key: FTVWIRXFELQLPI-ZDUSSCGKSA-N

    InChi Code: InChI=1S/C15H12O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-6,13,16-18H,7H2/t13-/m0/s1

    SMILES Code: O=C1C[[email protected]@H](C2=CC=C(O)C=C2)OC3=CC(O)=CC(O)=C13           

    SynonymsNSC 34875, S-Dihydrogenistein, NSC 11855; Salipurol; Naringenin;NSC-11855; NSC11855


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    In Vitro

    In vitro activity: Naringenin is a flavonoid that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, anti-inflammatory, carbohydrate metabolism promoter, and immune system modulator. Naringenin is the predominant flavanone in grapefruit. This substance has also been shown to reduce oxidative damage to DNA in vitro. Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P450 isoform CYP1A2, which can change pharmacokinetics in a human (or orthologous) host of several popular agents in an adverse manner, even resulting in carcinogens of otherwise harmless substances.


    Cell Assay: Naringenin is dissolved in DMSO and diluted in cell culture medium. The cells are rinsed with PBS and grown in a medium containing various concentrations of naringenin (50, 100, 150, 200, 250, 300 μM). The solvent DMSO treated cells are served as control. After 24 hrs of treatment, the medium is removed and replaced by another medium containing MTT. Cell viability is measured using the MTT assay

    In VivoIntragastrically administered Naringenin (50 mg/kg) induces a significant decrease in plasma glucose in normoglycaemic and non-insulin-dependent diabetes mellitus (NIDDM) rat models. LD50: Mice >5g/kg; Rats >5g/kg.
    Animal modelRats
    Formulation & Dosage50 mg/kg; i.g.
    References

    Carcinogenesis. 1990 Dec;11(12):2275-9; Diabetes Obes Metab. 2008 Nov;10(11):1097-104.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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