Ozagrel

Alias: Ozagrel Sodium;OKY-046;OKY046;OKY 046;Ozagrel; KCT-0809; KCT 0809; KCT0809; Cataclot; Xanbo; Ozagrel free acid
Cat No.:V0818 Purity: ≥98%
Ozagrel (OKY046;KCT-0809;OKY046;Cataclot;KCT0809;Xanbo),an antiplatelet agent, is a potent and selective inhibitor of thromboxane A2 (TXA2 synthetase (IC50 = 11 nM) with antiplatelet activity.
Ozagrel Chemical Structure CAS No.: 82571-53-7
Product category: P450 (e.g. CYP)
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
50mg
100mg
250mg
500mg
Other Sizes

Other Forms of Ozagrel:

  • Ozagrel Sodium
  • Ozagrel HCl (OKY046 HCl; KCT0809; Cataclot)
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Ozagrel (OKY046; KCT-0809; OKY046; Cataclot; KCT0809; Xanbo),an antiplatelet agent, is a potent and selective inhibitor of thromboxane A2 (TXA2 synthetase (IC50 = 11 nM) with antiplatelet activity. It has the potential use for for the improving postoperative cerebrovascular contraction and accompanying cerebral ischaemia.

Biological Activity I Assay Protocols (From Reference)
ln Vitro

In vitro activity: Ozagrel increased 6-keto-PGF1 alpha, one of stable metabolites of PGI2, in various isolated cells and tissues perhaps via accumulated PG endoperoxides resulted by the inhibition of TXA2 synthase.

ln Vivo
Ozagrel prevents oleic acid (OA) induced thromboxane A(2) generation and subsequently increased total protein concentration and the numbers of macrophages and neutrophils in bronchoalveolar lavage fluid and increased monocyte chemoattractant protein-1 andinterleukin-8 mRNA expression in the whole lung of guinea pigs. Ozagrel (3 mg/kg) decreases both the area and volume of the cortical infarction after ischemia-reperfusion of the middle cerebral artery in rat. Ozagrel also has suppressive effects on the neurologic deficits in the microthrombosis rat model. Ozagrel improves the reduced spontaneously locomotor activity and the obstruction of motor coordination in the conscious cerebral ischemia-reperfusion mouse model. Ozagrel suppresses the decrease in specific gravity of the brain tissue induced by the occlusion-reperfusion in the conscious cerebral ischemia-reperfusion SHR model, and recovers the postischemic decrease in cortical PO(2) after middle cerebral artery occlusion-reperfusion in cats. Ozagrel also increases the level of 6-keto-PGF(1alpha), a metabolite of prostaglandin I(2) (PGI(2)), in the brain tissue after cerebral ischemia-reperfusion, and the administration of PGI(2) improves the reduced spontaneous locomotor activity in the conscious cerebral ischemia-reperfusion mouse model. Ozagrel administered intravenously 30 min before oleic acid injection prevents the decrease in Pao(2) and pulmonary vascular hyper-permeability in guinea-pigs. Ozagrel also prevents increases in lactate dehydrogenase activity, a measure of lung cell injury, TXB(2) and its weight ratio to 6-keto prostaglandin F(1alpha) in bronchoalveolar lavage fluid in guinea-pigs.
Animal Protocol
3 mg/kg
Guinea pigs
References
J Pharmacol Sci.2009 Oct;111(2):211-5;Pharmacology.1999 Nov;59(5):257-65.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C13H12N2O2
Molecular Weight
228.25
CAS #
82571-53-7
SMILES
O=C(O)/C=C/C1=CC=C(CN2C=CN=C2)C=C1
InChi Key
SHZKQBHERIJWAO-AATRIKPKSA-N
InChi Code
InChI=1S/C13H12N2O2/c16-13(17)6-5-11-1-3-12(4-2-11)9-15-8-7-14-10-15/h1-8,10H,9H2,(H,16,17)/b6-5+
Chemical Name
(E)-3-(4-((1H-imidazol-1-yl)methyl)phenyl)acrylic acid
Synonyms
Ozagrel Sodium;OKY-046;OKY046;OKY 046;Ozagrel; KCT-0809; KCT 0809; KCT0809; Cataclot; Xanbo; Ozagrel free acid
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 46 mg/mL (201.5 mM)
Water:<1 mg/mL
Ethanol:<1 mg/mL
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 4.3812 mL 21.9058 mL 43.8116 mL
5 mM 0.8762 mL 4.3812 mL 8.7623 mL
10 mM 0.4381 mL 2.1906 mL 4.3812 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

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An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?
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  • The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
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  • The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box
g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
Instructions to calculate molar mass (molecular weight) of a chemical compound:
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
  • Molecular mass (or molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
  • Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
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Reconstitution Calculator allows you to calculate the volume of solvent required to reconstitute your vial.

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In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

Biological Data
  • Ozagrel


    Effects of ozagrel on serum ALT level and survival rate in APAP-induced liver injury.BMC Gastroenterol. 2013; 13: 21.

  • Ozagrel

    Effects of ozagrel on hepatic cell death-related markers in liver induced by APAP injection.BMC Gastroenterol. 2013; 13: 21.


  • Ozagrel

    Effects of ozagrel on hepatic GSH depletion induced by APAP and CYP 2E1 level.BMC Gastroenterol. 2013; 13: 21.
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