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      U-104
      U-104

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      This product is for research use only, not for human use. We do not sell to patients.
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      InvivoChem Cat #: V0895
      CAS #: 178606-66-1Purity ≥98%

      Description: U-104 (MST-104; U104; SLC-0111; NSC-213841) is a novel and potent inhibitor of transmembrane carbonic anhydrase (CA) with potential antineoplastic activity. It inhibits CA IX and CA XII with Ki values of 45.1 nM and 4.5 nM respectively. U-104 shows high in vivo antitumor efficacy in Balb/c mice orthotopically implanted with 4T1 cells.

      References: Cancer Res. 2011 May 1;71(9):3364-76; Oncogene. 2013 Oct 31;32(44):5210-9.

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      Molecular Weight (MW)309.32
      FormulaC13H12FN3O3S
      CAS No.178606-66-1
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 62 mg/mL (200.4 mM)
      Water: < 1 mg/mL
      Ethanol: < 1 mg/mL
      Solubility (In vivo)30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL
      SynonymsMST-104, SLC0111; SLC 0111; U-104; NSC 213841; MST104;  MST 104; NSC-213841; NSC213841; SLC-0111; U104; U 104.


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      In Vitro

      In vitro activity: U-104 (50  μM) blocks the mesenchymal phenotype in the cancer stem cells population in hypoxia condition of 4T1 cells. U-104 (<50  μM) significantly reduces migration in a dose-dependent manner in metastatic MDA-MB-231 LM2-4Luc+ cells , with cells growing as compact colonies similar to parental MDA-MB-231 cells. U-104 possesses aromatic groups at the second nitrogen ureido group.

      Cell Assay: U-104 (50 μM) blocks the mesenchymal phenotype in the cancer stem cells population in hypoxia condition of 4T1 cells. U-104 (<50 μM) significantly reduces migration in a dose-dependent manner in metastatic MDA-MB-231 LM2-4Luc+ cells , with cells growing as compact colonies similar to parental MDA-MB-231 cells.

      In VivoU-104 (38 mg/kg) inhibits primary tumor growth in the mice implanted orthotopically with MDA-MB-231 LM2-4Luc+ cells. U-104 (19 mg/kg) inhibits metastases formation in the 4T1 experimental metastasis mice model. U-104 (38 mg/kg) significantly delay primary tumor growth and reduces cancer stem cell population in NOD/SCID mice orthotopically implanted with MDA-MB-231 LM2-4Luc+ cells. U-104 (5 mg/mL, oral gavage) shows a significant delay in tumor growth in Balb/c mice orthotopically implanted with 4T1 cells.
      Animal modelBalb/c mice orthotopically implanted with 4T1 cells.
      Formulation & DosageDissolved in 55.6% PEG 400, 11.1% ethanol and 33% water; 5 mg/kg; oral gavage
      ReferencesCancer Res. 2011 May 1;71(9):3364-76; Oncogene. 2013 Oct 31;32(44):5210-9.

      These protocols are for reference only. InvivoChem does not independently validate these methods.

      U-104

      The metastatic 4T1 primary tumor is a valid preclinical model of hypoxia-induced CAIX expression. Cancer Res. 2011 May 1;71(9):3364-76. 
      		 

      U-104

      Silencing CAIX expression in metastatic 4T1 cells inhibits cell survival and alters pHe in hypoxia. Cancer Res. 2011 May 1;71(9):3364-76.  
      		 

      U-104

      Growth of primary breast tumors characterized by hypoxia requires the expression of CAIX. Cancer Res. 2011 May 1;71(9):3364-76. 
       

      U-104

      Inhibition of CAIX expression or activity attenuates metastasis of 4T1 mouse mammary tumors. Cancer Res. 2011 May 1;71(9):3364-76. 
      		 

      U-104

      Targeting CAIX activity with selective small molecule inhibitors of CAIX attenuates the growth of mouse and human breast tumors. Cancer Res. 2011 May 1;71(9):3364-76. 
      		 

      U-104

      Novel selective small molecule inhibitors of CAIX inhibit metastasis formation by 4T1 mammary tumor cells. Cancer Res. 2011 May 1;71(9):3364-76. 

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