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    Methocarbamol
    Methocarbamol

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0897
    CAS #: 532-03-6Purity ≥98%

    Description: Methocarbamol (Robaxin; AHR85; Lumirelax; AHR-85; Metocarbamolo), a carbamate analog of guaifenesin, is a potent carbonic anhydrase inhibitor (CAI) with sedative and musculoskeletal relaxant properties. It is used as a central muscle relaxant for the treatment of skeletal muscle spasms. 

    References: J Vet Pharmacol Ther. 2014 Feb;37(1):25-34; Equine Vet J Suppl. 1992 Feb;(11):41-4.

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    Molecular Weight (MW)241.24
    FormulaC11H15NO5
    CAS No.532-03-6
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 48 mg/mL (199.0 mM) 
    Water: < 1 mg/mL
    Ethanol: 48 mg/mL (199.0 mM) 
    SMILESOC(COC1=CC=CC=C1OC)COC(N)=O
    SynonymsAHR 85; Methocarbamol; Robaxin; Lumirelax; AHR-85; AHR85; Metocarbamolo


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    In Vitro

    In vitro activity: Methocarbamol is metabolized via dealkylation and hydroxylation followed by conjugation to form both glucuronides and sulfates.

    In VivoMethocarbamol results in a median terminal half-life, mean transit time, mean absorption time, and apparent oral clearance of 2.89 hours, 2.67 hours, 0.410 hours, and 16.5 mL/min/kg in the horse. Methocarbamol is rapidly absorbed and extensively metabolized after oral administration to horses as indicated by a short absorption time and modest systemic bioavailability of 54.4% in the horse. Methocarbamol is a centrally acting muscle relaxant available in both IV and oral forms in cats. Methocarbamol (100 mg/kg) does not change the heart rate, cardiac output, mean pulmonary arterial blood pressure, systolic, diastolic and mean aortic blood pressure, respiratory rate and arterial blood gases, but mild to moderate depression is observed in five of eight horses administered i.v. Methocarbamol, and in all horses administered oral Methocarbamol. Plasma Methocarbamol concentration declines very rapidly during the initial or rapid disposition phase after i.v. administration; the terminal elimination half-life ranged from 59 minutes to 90 minutes in horse. Peak plasma Methocarbamol concentrations following oral administration occur within 15 to 45 minutes in horse.
    Animal modelHorse
    Formulation & Dosage16.5 mL/min/kg i
    References

    J Vet Pharmacol Ther. 2014 Feb;37(1):25-34; Equine Vet J Suppl. 1992 Feb;(11):41-4.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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