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    Methazolamide
    Methazolamide

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0900
    CAS #: 554-57-4Purity ≥98%

    Description: Methazolamide (Neptazaneat; Naptazane; CL-8490; CL8490) is a highly potent and selective  inhibitor of carbonic anhydrase (CAI) with important biological activity. It inhibits the isoforms of CA such as hCA I, hCA II and bCA IV with Ki of 50 nM, 14 nM and 36 nM, respectively. Methazolamide is used to glaucoma (to lower the intraocular pressure inside the eyes).

    References: Bioorg Med Chem Lett. 2003;13(5):841-5; Am J Physiol Regul Integr Comp Physiol. 2009;297(3):R648-54.

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    • 香港大学
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    Molecular Weight (MW)236.27
    FormulaC5H8N4O3S2
    CAS No.554-57-4
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 47 mg/mL (198.9 mM)
    Water: < 1 mg/mL
    Ethanol: 3 mg/mL (12.7 mM)
    SMILESCC(/N=C1SC(S(=O)(N)=O)=NN/1C)=O
    SynonymsMethenamide; Neptazaneat; Naptazane; CL 8490; Methazolamide; Neptazane; N Methylacetazolamide;N-Methylacetazolamide; CL8490; CL-8490


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    In Vitro

    In vitro activity: Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. Methazolamide is of strength equal to acetazolamide, another carbonic anhydrase inhibitor used to treat irregular breathing disorders. However, methazolamide differs from acetazolamide in that it fails to activate Ca2+-dependent potassium channels in skeletal muscles.


    Kinase Assay: Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.

    In VivoMethazolamide does not impair respiratory work performance in anesthetized rabbits. 
    Animal modelRabbits
    Formulation & DosageN/A
    References

    Bioorg Med Chem Lett. 2003 Mar 10;13(5):841-5; Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R648-54.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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