Topiramate

Alias: Topiramate; MCN 4853; RWJ 17021;HSDB-7531; HSDB7531; Tipiramato; Topax; MCN-4853;HSDB 7531;RWJ-17021;MCN4853; RWJ17021
Cat No.:V0894 Purity: ≥98%
Topiramate (MCN-4853; RWJ-17021;HSDB-7531; Tipiramato; Topax)isan approved anticonvulsant (antiepilepsy) drug usedto treat certain types of seizures.
Topiramate Chemical Structure CAS No.: 97240-79-4
Product category: Carbonic Anhydrase
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
50mg
100mg
250mg
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1g
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Other Forms of Topiramate:

  • Topiramate lithium
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Topiramate (MCN-4853; RWJ-17021; HSDB-7531; Tipiramato; Topax) is an approved anticonvulsant (antiepilepsy) drug used to treat certain types of seizures. As a mutil-targeted inhibitor, it has been reported to interact with various ion channel types, such as AMPA/kainate receptors, voltage-sensitive Na+ channels, NMDA receptors and GABA receptors.

Biological Activity I Assay Protocols (From Reference)
ln Vitro
It has long been thought that topiramate is an antiepileptic medication that prevents seizures from spreading. Thus far, its mechanisms of action have been demonstrated to include potentiation of GABA (γ-amino-butyric acid)-induced Cl-influx, use-dependent inhibition of voltage-dependent Na+ channels in neurons, and inhibitory effects on inward currents through antagonistic interactions with kainate/alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors[2].
ln Vivo
Topiramate (25-100 mg/kg, i.p.) produces a dose-dependent elevation in the threshold for clonic seizures induced by infusion of ATPA, a selective agonist of GluR5 kainate receptors. Topiramate effectively suppresses acute seizures induced by perinatalhypoxia in a dose-related manner with a calculated ED50 of 2.1 mg/kg, i.p. Topiramate (20 and 40 mg/kg i.p.) inhibits both tonic and absence-like seizures in a dose-dependent manner, whereas Phenytoin (20 mg/kg i.p.) and Zonisamide (40 mg/kg i.p.) inhibits only the tonic seizures. Topiramate inhibits sound-induced seizures in DBA/2 mice (ED50 = 8.6 mg/kg p.o.).
Animal Protocol
25 ~ 100 mg/kg; i.p. injection
Male NIH Swiss mice
References
[1]. Kaminski RM, et al. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46(8):1097-104.
[2]. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56.
[3]. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C12H21NO8S
Molecular Weight
339.36
CAS #
97240-79-4
SMILES
NS(OC[C@]1(OC(C)(C)O2)[C@@H]2[ C@H](OC(C)(C)O3)[ C@H]3CO1)(=O)=O
Synonyms
Topiramate; MCN 4853; RWJ 17021;HSDB-7531; HSDB7531; Tipiramato; Topax; MCN-4853;HSDB 7531;RWJ-17021;MCN4853; RWJ17021
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 68 mg/mL (200.4 mM)
Water:< 1 mg/mL
Ethanol:68 mg/mL (200.4 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 2.9467 mL 14.7336 mL 29.4672 mL
5 mM 0.5893 mL 2.9467 mL 5.8934 mL
10 mM 0.2947 mL 1.4734 mL 2.9467 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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