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    Tioxolone
    Tioxolone

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0896
    CAS #: 4991-65-5Purity ≥98%

    Description: Tioxolone (Thioxolone) is a potent inhibitor of metalloenzyme carbonic anhydrase I with a variety of activities such as cytostatic, antipsoriatic, anti-acne, antibacterial and anti-mycotic properties. It inhibits carbonic anhydrase I with a Ki of 91 NM. Tioxolone is also added to some cosmetics (e.g. hair shampoos and skin cleansers), due to claims for its oil-regulating and antibacterial properties. 

    References: Acta Crystallogr C. 2004 Jun;60(Pt 6):o395-6; Exp Mol Med. 2011 May 31;43(5):313-21.

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    Molecular Weight (MW)168.17
    FormulaC7H4O3S
    CAS No.4991-65-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 34 mg/mL (202.2 mM)
    Water: < 1 mg/mL
    Ethanol: 34 mg/mL (202.17 mM)
    SMILESO=C1OC2=CC(O)=CC=C2S1
    SynonymsTioxolone; Thioxolone; 


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    In Vitro

    In vitro activity: Tioxolone is reported to possess cytostatic, antipsoriatic, antibacterial and anti-mycotic properties. Tioxolone is also added to some cosmetics (e.g. hair shampoos and skin cleansers), due to claims for its oil-regulating and antibacterial properties. The three-dimensional framework of Tioxolone is further stabilized by π-π interactions between the oxathiolone and benzene rings in partially overlapping molecules.

    In VivoTioxolone, a Benzoxathiol derivatives, has been used in the local therapy of psoriasis vulgaris and acne, and also reported to have anti-bacterial, anti-mycotic, and cytostatic properties.
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    References

    Acta Crystallogr C. 2004 Jun;60(Pt 6):o395-6; Exp Mol Med. 2011 May 31;43(5):313-21.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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