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    Mefenamic Acid (CI 473; CN-35355)
    Mefenamic Acid (CI 473; CN-35355)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1073
    CAS #: 61-68-7Purity ≥98%

    Description: Mefenamic Acid (CI-473; CN-35355; CI 473; CN 35355; Mefenamic Acid; Ponstel; Parkemed; Coslan), a nonsteroidal anti-inflammatory drug (NSAID), is potent, nonselective, competitive inhibitor of the enzymes COX-1 and COX-2 with anti-inflammatory activity. Mefenamic acid displays a wide range of biological acitivity such as anti-inflammatory, analgesic, and antipyretic properties. It also demonstrated potent anti-proliferative activity in vitro against colorectal cancer cells. 

    References: J Ethnopharmacol. 2015 Jul 21;170:106-16; Complement Ther Clin Pract. 2016 Feb;22:12-5.

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    Molecular Weight (MW)241.29 
    FormulaC15H15NO2 
    CAS No.61-68-7 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 48 mg/mL (198.9 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 2-(2,3-dimethylanilino)benzoic acid

    InChi Key: HYYBABOKPJLUIN-UHFFFAOYSA-N

    InChi Code: InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/ h3-9,16H,1-2H3,(H,17,18)

    SMILES: c1(c(cccc1)C(=O)O)Nc1c(c(ccc1)C)C

    SynonymsCI-473; CN-35355; CI473; CN35355; CI 473; CN 35355; Mefenamic Acid; Ponstel; Parkemed; Coslan


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    In Vitro

    In vitro activity: Mefenamic acid is a non-steroidal anti-inflammatory agent, acting as a competitive inhibitor of hCOX-1, with IC50s of 40 nM and 3 μM for hCOX-1 and hCOX-2, respectively. Mefenamic acid (0-100 μM) has cytotoxic effects on KB, Saos-2, and 1321N cells, however, U-87MG cells are resistant to Mefenamic acid.


    Cell Assay: Powder forms of Mefenamic acid, indometacin, aspirin, and celecoxib are dissolved in 0.1% dimethyl sulfoxide (DMSO) to achieve a concentration of 100 μM of stock solution, which is sterilized by filtration through a 0.22-µm filter and then stored at 4°C. Different concentrations (100, 50, 25, 10, and 5 μM) of the drugs (Mefenamic acid, etc.) are prepared by serial dilutions with the FCS-free medium or the medium containing 10% FCS in sterile plastic centrifuge tubes

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    References

    [1]. Gierse JK, et al. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305 (Pt 2):479-84.

    [2]. Hashemipour MA, et al. In Vitro Cytotoxic Effects of Celecoxib, Mefenamic Acid, Aspirin and Indometacin on Several Cells Lines. J Dent (Shiraz). 2016 Sep;17(3):219-25.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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