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      Meclofenamate Sodium (Meclofenamic acid sodium)
      Meclofenamate Sodium (Meclofenamic acid sodium)

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      This product is for research use only, not for human use. We do not sell to patients.
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      InvivoChem Cat #: V1047
      CAS #: 6385-02-0 Purity ≥98%

      Description: Meclofenamate Sodium (Meclonax; Meclomen; INF-4668; INF4668; CI 583; CI-583; Meclodium; Meclofenamic acid sodium) is a potent nonsteroidal anti-inflammatory drug (NSAID), acting as a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively. It is used in the treatment of joint, muscular pain, arthritis and dysmenorrhea. Meclofenamate sodium is a potent nonsteroidal antiinflammatory agent, specifically inhibits chemotactic factor-induced human polymorphonuclear leukocyte functions: chemotaxis, degranulation, and generation of superoxide anion radicals. These effects of MSM were found to be dependent upon the concentrations of drug not bound to albumin (free drug), and were caused by its ability to interfere at both a receptor and post-receptor level. 

      References: J Mol Cell Cardiol. 2016 May;94:131-44;

      Related CAS#: 644-62-2 (free acid); 67254-91-5 (sodium hydrate)

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      Molecular Weight (MW)318.13
      FormulaC14H11Cl2NO2.Na
      CAS No.6385-02-0 (Meclofenamate Sodium); 
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 63 mg/mL (198.0 mM)
      Water: N/A
      Ethanol: 63 mg/mL (198.0 mM)
      Other infoChemical Name: sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate hydrate
      InChi Key: QHJLLDJTVQAFAN-UHFFFAOYSA-M
      InChi Code: InChI=1S/C14H11Cl2NO2.Na.H2O/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;1H2/q;+1;/p-1
      SMILES Code: O=C([O-])C1=CC=CC=C1NC2=C(Cl)C=CC(C)=C2Cl.[H]O[H].[Na+] 
      SynonymsINF 4668; CI583; Meclonax; Meclomen; INF-4668; INF4668; CI 583; CI-583; Meclodium; Sodium meclophenamate; Sodium meclofenamate 


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