Size | Price | Stock | Qty |
---|---|---|---|
500mg |
|
||
1g |
|
||
2g |
|
||
5g |
|
||
10g |
|
||
25g |
|
||
Other Sizes |
|
Purity: ≥98%
Bufexamac (formerly also known as CP-1044-J-3; CP1044J3; Droxaryl; Parfenac; Bufexamic acid), a non-steroidal anti-inflammatory drug/NSAID, is a potent COX enzyme inhibitor with potential anti-inflammatory activity. It inhibits IFN-α release with an EC50 of 8.9 μM. Bufexamac is also a specific inhibitor of class IIB HDAC (histone deacetylases) (HDAC6/10). Treatment of peripheral blood mononuclear cells with bufexamac blocks the secretion of the inflammatory cytokine IFN-α. Bufexamac is a frequent and relevant contact sensitizer and also used as an anti-inflammatory agent belong to the NSAID (non-steroidal anti-inflammatory drug) class.
ln Vitro |
|
||
---|---|---|---|
ln Vivo |
|
||
Animal Protocol |
|
||
References |
Nat Biotechnol.2011 Mar;29(3):255-65.
|
Molecular Formula |
C12H17NO3
|
|
---|---|---|
Molecular Weight |
223.27
|
|
CAS # |
2438-72-4
|
|
SMILES |
O(C1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])C(N([H])O[H])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
|
|
InChi Key |
MXJWRABVEGLYDG-UHFFFAOYSA-N
|
|
InChi Code |
InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)
|
|
Chemical Name |
2-(4-butoxyphenyl)-N-hydroxyacetamide
|
|
Synonyms |
|
|
Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
|
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
Solubility (In Vitro) |
|
---|
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 4.4789 mL | 22.3944 mL | 44.7888 mL | |
5 mM | 0.8958 mL | 4.4789 mL | 8.9578 mL | |
10 mM | 0.4479 mL | 2.2394 mL | 4.4789 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.