Bufexamac (Bufexamic acid)

Alias: CP 1044 J 3;Bufexamic acid; CP-1044-J-3; CP1044J3; Droxaryl; Parfenac
Cat No.:V1063 Purity: ≥98%
Bufexamac (formerly also known as CP-1044-J-3; CP1044J3; Droxaryl; Parfenac; Bufexamic acid),a non-steroidal anti-inflammatory drug/NSAID, is a potentCOX enzyme inhibitor with potential anti-inflammatory activity.
Bufexamac (Bufexamic acid) Chemical Structure CAS No.: 2438-72-4
Product category: COX
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
500mg
1g
2g
5g
10g
25g
Other Sizes
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Bufexamac (formerly also known as CP-1044-J-3; CP1044J3; Droxaryl; Parfenac; Bufexamic acid), a non-steroidal anti-inflammatory drug/NSAID, is a potent COX enzyme inhibitor with potential anti-inflammatory activity. It inhibits IFN-α release with an EC50 of 8.9 μM. Bufexamac is also a specific inhibitor of class IIB HDAC (histone deacetylases) (HDAC6/10). Treatment of peripheral blood mononuclear cells with bufexamac blocks the secretion of the inflammatory cytokine IFN-α. Bufexamac is a frequent and relevant contact sensitizer and also used as an anti-inflammatory agent belong to the NSAID (non-steroidal anti-inflammatory drug) class.

Biological Activity I Assay Protocols (From Reference)
ln Vitro

In vitro activity: Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Treatment of peripheral blood mononuclear cells with bufexamac inhibits the secretion of IFN-α. Bufexamac is a frequent and relevant contact sensitizer. Bufexamac is a non-steroidal anti-inflammatory drug.

ln Vivo

Animal Protocol


References
Nat Biotechnol.2011 Mar;29(3):255-65.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C12H17NO3
Molecular Weight
223.27
CAS #
2438-72-4
SMILES
O(C1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])C(N([H])O[H])=O)C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H]
InChi Key
MXJWRABVEGLYDG-UHFFFAOYSA-N
InChi Code
InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)
Chemical Name
2-(4-butoxyphenyl)-N-hydroxyacetamide
Synonyms
CP 1044 J 3;Bufexamic acid; CP-1044-J-3; CP1044J3; Droxaryl; Parfenac
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO:45 mg/mL (201.5 mM)
Water:<1 mg/mL
Ethanol:3 mg/mL (13.4 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 4.4789 mL 22.3944 mL 44.7888 mL
5 mM 0.8958 mL 4.4789 mL 8.9578 mL
10 mM 0.4479 mL 2.2394 mL 4.4789 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

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Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
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g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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In vivo Formulation Calculator (Clear solution)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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