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Bufexamac (Bufexamic acid)

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InvivoChem Cat #: V1063

CAS #: 2438-72-4Purity ≥98%

Description: Bufexamac (formerly also known as CP-1044-J-3; CP1044J3; Droxaryl; Parfenac; Bufexamic acid), a non-steroidal anti-inflammatory drug/NSAID, is a potent COX enzyme inhibitor with potential anti-inflammatory activity. It inhibits IFN-α release with an EC50 of 8.9 μM. Bufexamac is also a specific inhibitor of class IIB HDAC (histone deacetylases) (HDAC6/10). Treatment of peripheral blood mononuclear cells with bufexamac blocks the secretion of the inflammatory cytokine IFN-α. Bufexamac is a frequent and relevant contact sensitizer and also used as an anti-inflammatory agent belong to the NSAID (non-steroidal anti-inflammatory drug) class.

References: Nat Biotechnol. 2011 Mar;29(3):255-65.

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Molecular Weight (MW)	223.27
Formula	C12H17NO3
CAS No.	2438-72-4
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility (In vitro)	DMSO: 45 mg/mL (201.5 mM)
	Water: <1 mg/mL
	Ethanol: 3 mg/mL (13.4 mM)
Other info	Chemical Name: 2-(4-butoxyphenyl)-N-hydroxyacetamide InChi Key: MXJWRABVEGLYDG-UHFFFAOYSA-N InChi Code: InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14) SMILES Code: O=C(NO)CC1=CC=C(OCCCC)C=C1
Synonyms	CP 1044 J 3; Bufexamic acid; CP-1044-J-3; CP1044J3; Droxaryl; Parfenac

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In Vitro	In vitro activity: Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Treatment of peripheral blood mononuclear cells with bufexamac inhibits the secretion of IFN-α. Bufexamac is a frequent and relevant contact sensitizer. Bufexamac is a non-steroidal anti-inflammatory drug.
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References	Nat Biotechnol. 2011 Mar;29(3):255-65.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Purity ≥98%
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