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    Asaraldehyde (Asaronaldehyde)
    Asaraldehyde (Asaronaldehyde)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1076
    CAS #: 4460-86-0Purity ≥98%

    Description: Asaraldehyde (also called Asaronaldehyde; 2,4,5-trimethoxy-Benzaldehyde), a naturally occuring compound extracted from carrot (Daucus carota L.) seeds, is a potent COX-2 enzyme inhibitor with potential anti-inflammatory activity. It inhibits COX-2 with an IC50 of 100 μg/mL and exhibits 17-fold selectivity for COX-2 over COX-1. 

    References: Lett Appl Microbiol. 2007 Apr;44(4):387-92; Phytother Res. 2003 Sep;17(8):976-9.

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    Molecular Weight (MW)196.2 
    FormulaC10H12O4 
    CAS No.4460-86-0  
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 39 mg/mL (198.8 mM) 
    Water: <1 mg/mL
    Ethanol: 16 mg/mL (81.5 mM)
    SMILESO=CC1=CC(OC)=C(OC)C=C1OC
    SynonymsAsaronaldehyde; Asaraldehyde; 2,4,5-trimethoxy-Benzaldehyde


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    In Vitro

    In vitro activity: Asaraldehyde is found to be the most abundant constituent, but is totally absent in its cultured broth and its natural host, C. kanehirae wood. On feeding with the acid-digested sawdust of C. kanehirae wood or vanillin to the broth for culture, Asaraldehyde is produced in both cultured broths. Asaraldehyde shows 3.32% of prostaglandin H endoperoxide synthase-1 (COX-1) inhibitory activity and 52.69% prostaglandin H endoperoxide synthase-2 (COX-2) inhibitory activity, respectively at 100 mg/mL. Asaraldehyde shows selectivity towards COX-2 enzyme inhibition at 100 µg/mL. The COX-2/COX-1 ratio for Asaraldehyde is 17.68 at 100 µg/mL compared to solvent control. Asaraldehyde down-regulates C/EBPβ, C/EBPδ, and C/EBPα. Asaraldehyde suppresses expression of PPARγ1 and PPARγ2. Asaraldehyde also significantly suppresses the expression of acetyl-CoA carboxylase (ACC).


    Cell Assay: 3T3-L1 cells are seeded in 96-well plates at a concentration of 104 /well. Twenty-four hours after seeding, the cells are treated with 100 μg/mL of Asaraldehyde for 24 hours or for the whole 8-day differentiation period. Fully differentiated adipocytes are also treated with 100 μg/mL of Asaraldehyde for 24 hours-72 hours to test the cytotoxicity. At the end of treatment, cells are cultured with MTT at a final concentration of 0.5 mg/mL for another 4 hours. The purple MTT formazan is dissolved by DMSO and the absorbance at 570 nm is taken with a spectrophotometer. The absorbance is proportional to the viability of adipocytes.

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    References

    Lett Appl Microbiol. 2007 Apr;44(4):387-92; Phytother Res. 2003 Sep;17(8):976-9. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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