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    Bromfenac Sodium (AHR 10282R)
    Bromfenac Sodium (AHR 10282R)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1048
    CAS #: 91714-93-1Purity ≥98%

    Description: Bromfenac Sodium (formerly AHR-10282R; AHR10282R; AHR-10282, AHR10282; trade names Prolensa, Bromday, Xibrom), an approved nonsteroidal anti-inflammatory drug (NSAID), is an orally bioavailable COX-1/2 inhibitor with anti-inflammatory activity. It can inhibit the biosynthesis of prostaglandin by blocking cyclooxygenase 1 and 2.

    References: Arzneimittelforschung. 1987 May;37(5):513-9; Drug Metab Dispos. 1998 Jul;26(7):720-3.

    Related CAS #: 91714-93-1 (sodium); 91714-94-2 (free acid)

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    Molecular Weight (MW)356.15 
    CAS No.91714-93-1 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 71 mg/mL (199.4 mM) 
    Water: 71 mg/mL (199.4 mM) 
    Ethanol: 2 mg/mL (5.6 mM)
    Other info

    Chemical Name: 2-Amino-3-(4-bromobenzoyl)benzeneacetic acid sodium


    InChi Code: InChI=1S/C15H12BrNO3.Na/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19;/h1-7H,8,17H2,(H,18,19);/q;+1/p-1

    SMILES Code: O=C(O)CC1=CC=CC(C(C2=CC=C(Br)C=C2)=O)=C1N

    SynonymsAHR 10282R; Bromfenac sodium, Prolensa, AHR-10282R; AHR10282R; Bromday, Xibrom, AHR-10282, AHR10282, AHR 10282

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    In Vitro

    In vitro activity: N/A

    In VivoBromfenac (bromfenac sodium) by the oral route at pretreatment times of 10 min, 20 min and 300 min is respectively 3.7, 6.5 and 2.9 times more potent than zomepirac and 3.4, 6.6, and 44.2 times more potent than suprofen in the acetylcholine abdominal constriction assay in mice. Bromfenac when given orally is 5.8 times more potent than zomepirac in blocking the nociceptive response to bradykinin in dogs. Bromfenac is 6.1 to 32.8 times more potent than indometacin in inhibiting the formation of prostaglandin E2 and F2 alpha from microsomes of bovine seminal vesicles, rabbit uteri, and rabbit renal medullae. Bromfenac, given orally, is more potent than indometacin in suppressing acute (7.5-20 times) and chronic (3.8 times) inflammation in mice. Bromfenac (1 mg/kg, i.v.) is metabolited into an unusual conjugate, bromfenac N-glucoside, in rats bile. Bromfenac shows a rapid onset of activity (20 min) that persisted for at least 4 hours in a mouse model of pain (acetylcholine abdominal constriction). Bromfenac (0.316 mg/kg) produces significant anti-inflammatory activity up to 24 hours after dosing in a rat model of inflammation (carrageenan foot edema). Bromfenac is readily absorbed after oral administration, peak plasma levels being achieved at the earliest time tested: 20 min in the mouse and 30 min in the rat.
    Animal modelMice, rats, dogs
    Formulation & DosageN/A

    Arzneimittelforschung. 1987 May;37(5):513-9; Drug Metab Dispos. 1998 Jul;26(7):720-3. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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