Xylometazoline HCl

Alias: xylomethazoline; Xylometazoline HCl; Brand name: Decongest; Otrivine; Balkis; Amidrin; Chlorohist-LA; espa-rhin; Gelonasal
Cat No.:V1125 Purity: ≥98%
Xylometazoline HCl (xylomethazoline; Otrivine; Amidrin; Balkis; Chlorohist-LA; Decongest; espa-rhin; Gelonasal),the hydrochloride salt of Xylometazoline, is an α-adrenoceptor agonist commonly used as nasal decongestant.
Xylometazoline HCl Chemical Structure CAS No.: 1218-35-5
Product category: Adrenergic Receptor
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
500mg
1g
2g
5g
10g
25g
Other Sizes

Other Forms of Xylometazoline HCl:

  • Xylometazoline
Official Supplier of:
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Purity & Quality Control Documentation

Purity: ≥98%

Product Description

Xylometazoline HCl (xylomethazoline; Otrivine; Amidrin; Balkis; Chlorohist-LA; Decongest; espa-rhin; Gelonasal), the hydrochloride salt of Xylometazoline, is an α-adrenoceptor agonist commonly used as nasal decongestant.shows maximum potency at the α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline, a α-adrenoceptor agonist that is frequently used as a nasal decongestant, has an EC50 of 99 μM and is most potent at the α2B-adrenoceptor subtype. With an IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, and 0.22 μM, respectively, xylometazoline binds at adrenoceptor subtypes α1A, α1B, α1D, α2A, α2B, and α2C.

Biological Activity I Assay Protocols (From Reference)
Targets
Alpha-1A adrenergic receptor ( Ki = 0.05 μM ); Alpha-1B adrenergic receptor ( Ki = 0.30 μM ); Alpha-1D adrenergic receptor ( Ki = 0.15 μM ); Alpha-2A adrenergic receptor ( Ki = 0.88 μM ); Alpha-2B adrenergic receptor ( Ki = 1.7 μM ); Alpha-2C adrenergic receptor ( Ki = 0.19 μM nM )
ln Vitro

In vitro activity: Xylometazoline, an α-adrenoceptor agonist that is frequently used as a nasal decongestant, has the highest potency at the α2B-adrenoceptor subtype with EC50 of 99 μM. At adrenoceptor subtypes α1A, α1B, α1D, α2A, α2B, and α2C, xylometazoline binds with IC50 values of 0.08, 0.56, 0.45, 0.98, 1.8, and 0.22μM, respectively.[1]

ln Vivo

Animal Protocol


References

[1]. Fundam Clin Pharmacol . 2010 Dec;24(6):729-39.

These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C16H25CLN2
Molecular Weight
280.84
Exact Mass
280.17
Elemental Analysis
C, 68.43; H, 8.97; Cl, 12.62; N, 9.98
CAS #
1218-35-5
Appearance
White to off-white crystalline powder
SMILES
CC1=CC(=CC(=C1CC2=NCCN2)C)C(C)(C)C.Cl
InChi Key
YGWFCQYETHJKNX-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H
Chemical Name
2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole;hydrochloride
Synonyms
xylomethazoline; Xylometazoline HCl; Brand name: Decongest; Otrivine; Balkis; Amidrin; Chlorohist-LA; espa-rhin; Gelonasal
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO: 25~27 mg/mL (89.0~96.1 mM)
Water: ~56 mg/mL (~199.4 mM)
Ethanol: ~56 mg/mL (~199.4 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 3.5607 mL 17.8037 mL 35.6075 mL
5 mM 0.7121 mL 3.5607 mL 7.1215 mL
10 mM 0.3561 mL 1.7804 mL 3.5607 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Calculator

Molarity Calculator allows you to calculate the mass, volume, and/or concentration required for a solution, as detailed below:

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An example of molarity calculation using the molarity calculator is shown below:
What is the mass of compound required to make a 10 mM stock solution in 5 ml of DMSO given that the molecular weight of the compound is 350.26 g/mol?
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  • The answer of 17.513 mg appears in the Mass box. In a similar way, you may calculate the volume and concentration.

Dilution Calculator allows you to calculate how to dilute a stock solution of known concentrations. For example, you may Enter C1, C2 & V2 to calculate V1, as detailed below:

What volume of a given 10 mM stock solution is required to make 25 ml of a 25 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=25 μM, V2=25 ml and V1 is the unknown:
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  • The answer of 62.5 μL (0.1 ml) appears in the Volume (Start) box
g/mol

Molecular Weight Calculator allows you to calculate the molar mass and elemental composition of a compound, as detailed below:

Note: Chemical formula is case sensitive: C12H18N3O4  c12h18n3o4
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
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  • Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
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Reconstitution Calculator allows you to calculate the volume of solvent required to reconstitute your vial.

  • Enter the mass of the reagent and the desired reconstitution concentration as well as the correct units
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  • The answer appears in the Volume (to add to vial) box
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal to make allowance for loss during the experiment)
Step 2: Enter in vivo formulation (This is only a calculator, not the exact formulation for a specific product. Please contact us first if there is no in vivo formulation in the solubility section.)
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Calculation results

Working concentration mg/mL;

Method for preparing DMSO stock solution mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation:Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
             (2) Be sure to add the solvent(s) in order.

Clinical Trial Information
NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT05334017 Completed Drug: Xylometazoline 0,1%
Drug: Cocaine 4%
Epistaxis Rigshospitalet, Denmark September 8, 2022 Phase 4
NCT03424889 Completed Drug: Xylometazoline
Drug: Saline
Bronchoscopy All India Institute of Medical
Sciences, New Delhi
June 1, 2018 Not Applicable
NCT00452270 Completed Drug: Xylometazoline Common Cold Novartis March 2007 Phase 3
NCT00622817 Completed Drug: xylometazoline HCL 0.05%
Drug: Epinephrine 1mg
Bronchiolitis Schneider Children's Medical
Center, Israel
October 2004 Not Applicable
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