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    Xylometazoline HCl
    Xylometazoline HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1125
    CAS #: 1218-35-5Purity ≥98%

    Description: Xylometazoline HCl (xylomethazoline; Otrivine; Amidrin; Balkis; Chlorohist-LA; Decongest; espa-rhin; Gelonasal), the hydrochloride salt of Xylometazoline, is an α-adrenoceptor agonist commonly used as nasal decongestant. It exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22μM, repectively.

    References: Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.

    Related CAS #: 1218-35-5 (HCl)   526-36-3 (free base)  

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    Molecular Weight (MW)280.84 
    FormulaC16H24N2.HCl 
    CAS No.1218-35-5 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 27 mg/mL (96.1 mM) 
    Water: 56 mg/mL (199.4 mM)
    Ethanol: 56 mg/mL (199.4 mM)
    Other infoChemical Name: 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole hydrochloride

    InChi Key: YGWFCQYETHJKNX-UHFFFAOYSA-N

    InChi Code: InChI=1S/C16H24N2.ClH/c1-11-8-13(16(3,4)5)9-12(2)14(11)10-15-17-6-7-18-15;/h8-9H,6-7,10H2,1-5H3,(H,17,18);1H

    SMILES Code: CC1=C(CC2=NCCN2)C(C)=CC(C(C)(C)C)=C1.[H]Cl

    SynonymsTrade name: Otrivine; Amidrin; Balkis; Chlorohist-LA; Decongest; espa-rhin; Gelonasal.


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    In Vitro

    In vitro activity: Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22μM, repectively.

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    References

    Fundam Clin Pharmacol. 2010 Dec;24(6):729-39. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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