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    ICI-118551 HCl
    ICI-118551 HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V3431
    CAS #: 72795-01-8Purity ≥98%

    Description: ICI-118551 HCl, the hydrochloride salt of ICI-118551, is a novel, potent and highly selective β2 adrenergic receptor antagonist, with Kis of 0.7, 49.5 and 611 nM for β2, β1 and β3 receptors, respectively. beta(2)-adrenoceptors are important modulators of vascular tone, particularly in the pulmonary circulation. ICI 118551 binding directs the beta(2)AR to a G(i)-coupled form and away from the G(s)-coupled form (ligand-directed trafficking). ICI 118,551 effectively acts as an agonist at the G(i)-coupled beta(2)AR, producing a direct negative inotropic effect. Conditions where beta(2)ARs are present and G(i) is raised (failing human heart, TGbeta(2) mouse heart) predispose to the appearance of the negative inotropic effect. 

    References:  2002 May 28;105(21):2497-503;  2009 Jul;54(1):157-63.

    Related CAS #: 72795-01-8 (HCl) 72795-26-7 (free base)  91021-57-7 (racemic)  

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    ICI-118551 HCl

    Name: ICI-118551 HCl
    CAS#: 72795-01-8 (HCl)
    Chemical Formula: C17H28ClNO2
    Exact Mass:
    Molecular Weight: 313.87
    Elemental Analysis: C, 65.06; H, 8.99; Cl, 11.29; N, 4.46; O, 10.19
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: ICI118551; ICI 118551; ICI-118551; ICI118,551; ICI 118,551; ICI-118,551; ICI-118551 HCl.
    Chemical Name: (2R,3R)-3-(isopropylamino)-1-((7-methyl-2,3-dihydro-1H-inden-4-yl)oxy)butan-2-ol hydrochloride
    InChi Key: KBXMBGWSOLBOQM-CACIRBSMSA-N
    InChi Code: InChI=1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16+;/m1./s1
    SMILES Code: C[[email protected]@H](NC(C)C)[[email protected]@H](O)COC1=CC=C(C)C2=C1CCC2.[H]Cl


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