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    Xylazine HCl (BAY 1470 HCl)
    Xylazine HCl (BAY 1470 HCl)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1080
    CAS #: 23076-35-9 Purity ≥98%

    Description: Xylazine HCl (Anased; BAY 1470; BAY-1470;Primazine; Rometar; Sedomin; WH-7286; Xilazina), the hydrochloride salt of xylazine and an analogue of clonidine, is an α2-Adrenergic receptor agonist that has been approved as a Veterinarian drug and used for sedation, muscle relaxation, anesthesia, and analgesia in big animals such as horses, cattles and other non-human mammals. Veterinarians also use xylazine as an emetic, especially in cats. In the analgesic testing, Xylazine has shown a significant prolongation of the analgesic effects in the presence of naloxine in 40 and 50 mins. 

    References: Can J Vet Res. 2002 Jan;66(1):42-9; Am J Vet Res. 2000 Oct;61(10):1225-31.

    Related CAS#: 7361-61-7 (free base)

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    Molecular Weight (MW)256.79
    CAS No.23076-35-9 (HCl); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 50 mg/mL (194.7 mM)
    Water: 12 mg/mL (46.73 mM)
    Ethanol: 50 mg/mL (194.7 mM)
    Other infoIUPAC/Chemical Name: 4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-, monohydrochloride
    InChi Code: InChI=1S/C12H16N2S.ClH/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12;/h3,5-6H,4,7-8H2,1-2H3,(H,13,14);1H
    SMILES Code: CC1=C(NC2=NCCCS2)C(C)=CC=C1.[H]Cl
    SynonymsBAY-VA 1470; BAY1470; Anased; BAY 1470; BAY-1470; Xylazine hydrochloride; Primazine; Rometar; Sedomin; WH 7286; Xilazina

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    In Vitro

    In vitro activity: Xylazine dose-dependently inhibits norepinephrine release and lipolysis in beagle dogs. Xylazine also tends to decrease epinephrine levels dose-dependently. Xylazine hydrochloride dose- and time-dependently reduces amount of minimum alveolar concentration (MAC) in horse.  Xylazine hydrochloride dose- and time-dependently increases blood glucose concentration in horse. Xylazine induces variable bilateral caudal analgesia extending from coccyx to S3, with minimal sedation, ataxia, and cardiovascular and respiratory depression in standing mares. Xylazine significantly decreases heart and respiratory rates, systolic, diastolic, and mean arterial blood pressure, PCV, hemoglobin concentration, arterial oxygen content, and oxygen transport. Xylazine results in significantly decreased heart rate, increased incidence of atrioventricular block, and decreased cardiac output and cardiac index in horse. Xylazine induces sedation and selective (S3 to Co) analgesia for at least 2 hours in cows. Xylazine significantly decreases heart rate, respiratory rate, rate of ruminal contractions, arterial blood pressure, PaO2, PCV, and total solids concentration, and significantly increases PaCO2, base excess, and bicarbonate concentration in cows. Xylazine severely depresses the N3 field (-75%) and completely abolishes the climbing fiber field (-100%) in the nonanesthetized, decerebrated rat. Xylazine- ketamine injections also severely depresses the N3 field (-75%) and nearly completely abolishes theclimbing fiber field (-90%) in the nonanesthetized, decerebrated

    In VivoAdministration of xylazine (0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl) induced approximately 2.5 hours of local analgesia without apparent side effects. Higher doses of xylazine caused mild hind limb ataxia. Administration of lidocaine induced a similar duration of analgesia, with severe hind limb ataxia (100% incidence). We concluded that xylazine given by epidural injection results in safe, effective perineal analgesia in horses
    Animal model Horse
    Formulation & Dosage 0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl; epidural injection
    ReferencesCan J Vet Res. 2002 Jan;66(1):42-9; Am J Vet Res. 2000 Oct;61(10):1225-31.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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