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    Yohimbine HCl
    Yohimbine HCl

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1127
    CAS #: 65-19-0Purity ≥98%

    Description: Yohimbine HCl (Antagonil; Corynine; Quebrachin; Quebrachine; Yohimex; Yocon; APHRODINE; Aphrodyne; Aphrosol; Johimbin), the hydrochloride salt of Yohimbine, is a potent alpha 2-adrenoreceptor antagonist used as a mydriatic for the treatment of impotence. It is an indole alkaloid derived from the bark of the Pausinystalia yohimbe tree in Central Africa. Yohimbine is also alleged to be an aphrodisiac. Yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei. 

    References: J Urol. 1998 Feb;159(2):433-6; J Neurosci. 2006 Nov 1;26(44):11442-53.

    Related CAS #: 65-19-0 (HCl)   146-48-5 (free base)   

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    Molecular Weight (MW)390.9 
    FormulaC21H26N2O3.HCl 
    CAS No.65-19-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 12 mg/mL (30.7 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: methyl (1R,2S,4aR,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate hydrochloride

    InChi Key: PIPZGJSEDRMUAW-VJDCAHTMSA-N

    InChi Code: InChI=1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5,12,15,17-19,22,24H,6-11H2,1H3;1H/t12-,15-,17-,18-,19+;/m0./s1

    SMILES: COC(=O)[[email protected]]1[[email protected]](CC[[email protected]@H]2[[email protected]@H]1C[[email protected]]3C4=C(CCN3C2)C5=CC= CC=C5N4)O

    SynonymsAntagonil; Yohimbine; Yohimbin; Corynine; Quebrachin; Quebrachine; Yohimex; Yocon; APHRODINE; (+)-Yohimbine; Aphrodyne; Aphrosol; Johimbin; Yohimbic acid methyl ester; Actibine; Thybine; Yohimar; Yovital; Yoman; Dayto himbin 


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    In Vitro

    In vitro activity: Yohimbine(Antagonil) has been used as a mydriatic and in the treatment of impotence. It is also alleged to be an aphrodisiac. Yohimbine is a pre-synaptic alpha 2-adrenergic blocking agent. Yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephrine release and in firing rate of cells in the brain noradrenergic nuclei.

    In VivoYohimbine hydrochloride (0.2 mg/kg, i.p.) was administered to rats 1h before the stress session daily for 14 consecutive days and its effect was assessed. Results of this section revealed that, immersion of rats in cold water significantly decreased sexual arousal and motivation as indicated by increased latencies and intervals. Decreased copulatory activity was confirmed by decreased testosterone, luteinizing hormone (LH) and follicle-stimulating-hormone (FSH) levels as well as decreased cholesterol content in rat testes. Treatment with yohimbine significantly increased the sexual arousal and potency and corrected the effects induced by stress on the mating behavior of male rats. 
    Animal modelRats
    Formulation & Dosage0.2 mg/kg, i.p.
    References

    J Urol. 1998 Feb;159(2):433-6; J Neurosci. 2006 Nov 1;26(44):11442-53. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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