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1g |
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2g |
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5g |
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10g |
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50g |
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200g |
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Other Sizes |
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Purity: ≥98%
Griseofulvin (Gris-PEG; Grifulvin; Fulvicin, Grisactin, Amudane), a naturally occurring spirocyclic compound isolated from some strains of the mold Penicillium griseofulvumam, is an oral antifungal medication approved for use in the treatment of various dermatophytoses (ringworm) such as fungal infections of the nails and skin when antifungal creams did not work. Griseofulvin is a tubulin/microtubule inhibitor that acts by inhibiting cell mitosis via interfering with microtubule function. Griseofulvin is used orally only for dermatophytosis. It is ineffective topically. It is reserved for cases with nail, hair, or large body surface involvement.
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ln Vivo |
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Animal Protocol |
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References |
Mutat Res.1988 Mar;195(2):91-126;Int J Cancer.2001 Feb 1;91(3):393-401.
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Molecular Formula |
C17H17CLO6
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Molecular Weight |
352.77
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CAS # |
126-07-8
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Related CAS # |
Griseofulvin;126-07-8
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SMILES |
O=C1[C@]2(C(OC)=CC(C[C@H]2C)=O)OC3=C(Cl)C(OC)=CC(OC)=C13
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InChi Key |
DDUHZTYCFQRHIY-RBHXEPJQSA-N
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InChi Code |
InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1
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Chemical Name |
(2S,6R)-7-chloro-2,4,6-trimethoxy-6-methyl-3H-spiro[benzofuran-2,1-cyclohexan]-2-ene-3,4-dione
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.8347 mL | 14.1735 mL | 28.3471 mL | |
5 mM | 0.5669 mL | 2.8347 mL | 5.6694 mL | |
10 mM | 0.2835 mL | 1.4174 mL | 2.8347 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.