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    INH6
    INH6

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1613
    CAS #: 1001753-24-7Purity ≥98%

    Description: INH6 is a potent and cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment. INH6 inhibited Hec1/Nek2 function through protein degradation that led to chromosome mis-segregation and cell death. In MDA-MB468 and MDA-MB231 human breast cancer cell lines, HeLa human cervical cancer line and K562 human erythromyeloblastoid leukemia cell line, INH6 exhibited significantly anti-proliferation activities with IC50 values of 2.1, 1.7, 2.4 and 2.5 µM, respectively.

    References: J Med Chem. 2009 Mar 26;52(6):1757-67. 

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    Molecular Weight (MW)322.42 
    FormulaC19H18N2OS 
    CAS No.1001753-24-7 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 64 mg/mL (198.5 mM)
    Water: <1 mg/mL
    Ethanol: 11 mg/mL  (34.1 mM) 
    Other info

    Chemical Name: N-[4-(2,4,6-Trimethylphenyl)-1,3-thiazol-2-yl]benzamide

    InChi Key: WCZLNJTXHZPHLM-UHFFFAOYSA-N

    InChi Code: InChI=1S/C19H18N2OS/c1-12-9-13(2)17(14(3)10-12)16-11-23-19(20-16)21-18(22)15-7-5-4-6-8-15/h4-11H,1-3H3,(H,20,21,22)

    SMILES Code: O=C(NC1=NC(C2=C(C)C=C(C)C=C2C)=CS1)C3=CC=CC=C3

    Synonyms

    INH6; INH-6; INH 6


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    In Vitro

    In vitro activity: INH6 effectively targets the Hec1/Nek2 complex for degradation, and shows potent cell killing activity with IC50 of 1.7, 2.1, 2.4, and 2.5 μM in MDA-MB231, MDA-MB468, HeLa and K562 cell lines. INH6 also triggers mitotic abnormalities in HeLa cells, and induces apoptosis.


    Cell Assay: Standard XTT assays with a four-day drug treatment procedure are performed to measure the dose-dependent cytotoxicity of INH analogs in cultured cells. Triplicate sets are measured and compiled for final data presentation. The assay is performed by using a commercial kit following the instructions. In principle, cells are plated on 96-well dishes one day before the drug treatment, followed by drug treatment on day 2 and XTT assay on day 5 after drug addition. The absorption at 595 nm is measured with a plate reader and converted to cell survival percentages in comparison to mock treated groups.

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    References

    J Med Chem. 2009 Mar 26;52(6):1757-67. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    INH6
    J Med Chem. 2009 Mar 26;52(6):1757-67.
     
    INH6
    J Med Chem. 2009 Mar 26;52(6):1757-67.
     
    INH6
    J Med Chem. 2009 Mar 26;52(6):1757-67.


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