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    CK-636 (CK-0944636)
    CK-636 (CK-0944636)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1616
    CAS #: 442632-72-6Purity ≥98%

    Description: CK-636 (also called CK636; CK-0944636; CK0944636) is a potent inhibitor of the actin-related protein (Arp2/3) complex with IC50 values of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively. CK-636 binds between Arp2 and Arp3 where it appears to block movement of Arp2 and Arp3 into their active conformation and inhibits Arp2/3 complex’s ability to nucleate actin filaments. In a concentration dependence way, CK-636 reduced the formation of actin filament comet tails by Listeria with IC50 value of 22 μM in infected SKOV3 cells. 

    References: Nature. 2009 Aug 20;460(7258):1031-4; PLoS One. 2013 Sep 12;8(9):e73960. 

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    Molecular Weight (MW)284.38 
    FormulaC16H16N2OS 
    CAS No.442632-72-6 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 57 mg/mL (200.4 mM)
    Water: <1 mg/mL
    Ethanol: 50 mg/mL (175.8 mM)
    Other info

    Chemical Name: N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide

    InChi Key: ACAKNPKRLPMONU-UHFFFAOYSA-N

    InChi Code: InChI=1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19)

    SMILES Code: O=C(C1=CC=CS1)NCCC2=C(C)NC3=C2C=CC=C3

    SynonymsCK0944636; CK636; CK-0944636; CK 636; CK 0944636; CK-636


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    In Vitro

    In vitro activity: CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns.

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    References

    Nature. 2009 Aug 20;460(7258):1031-4; PLoS One. 2013 Sep 12;8(9):e73960.  


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    CK-636

    Two classes of small molecules inhibit nucleation of actin filaments by Arp2/3 complex. Nature. 2009 Aug 20;460(7258):1031-4.
     

    CK-636

    Inhibition of actin assembly in live cells by CK-548, CK-636 and CK-666. Nature. 2009 Aug 20;460(7258):1031-4.
     

    CK-636


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