| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V4536 | SNIPER(ABL)-024 | 2222355-77-1 | SNIPER(ABL)-024 is a compound by conjugating GNF5 (an ABL inhibitor) to LCL161 derivative (IAP-inhibitor of apoptosis protein ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50of 5μM. |
|
V4945 | Solabegron HC1 | 451470-34-1 | Solabegron (formerly also known as GW 427353; GW-427353; GW-427,353) is a novel, potent and selective agonist for the β3 adrenergic receptor, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with anEC50value of 22 nM. |
|
V4950 | SR 11237 | 146670-40-8 | SR11237 (BMS-649) is a retinoid X receptor (RXR) selective agonist without any RAR activity. |
|
V5163 | SR142948A | 184162-64-9 | SR 142948A is a novel non-peptide Neurotensin receptor antagonist used in scientific research. |
|
V5115 | Symadex (XLS002, C1311) | 138154-39-9 | Symadex (formerly XLS-002, C-1311, andimidazoacridone) is a novel anticancer agent of the imidazoacridinone class which has been recommended for Phase II clinical trials a few years ago, it has shown activity in experimental tumour models both in vitro and in nude mice. |
|
V4588 | SYR-127063 | 871026-18-5 | SYR127063 (also known as BDBM92454) is a novel, potent and selective HER2 inhibitor with IC50 of 11 nM, 429 nM,> 10000 nM for HER2, EGFR, and HER4, respectively. |
|
V4580 | TAK-024 | 186971-69-7 | TAK-024 is a novel and potentplateletinhibitor withIC50s of 31, 79 and 51 nM in human, monkey and guinea pig, respectively. |
|
V4583 | TAK-071 | 1820812-16-5 | TAK-071 is a novel, potent and highly selectivemuscarinic acetylcholine receptor 1 (M1R)positive allosteric modulator (PAM). |
|
V4591 | TAK-220 | 333994-00-6 | TAK-220 (TAK220), a novel 1,4-disubstituted piperidine/piperazine, is a potent, selective and orally bioavailableCCR5antagonist withIC50s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively. |
|
V4584 | TAK-778 | 180185-61-9 | TAK-778, a derivative of ipriflavone, has been shown to induce bone growth both in vitro and in vivo. |
|
V4587 | TAK-828F | 1854901-94-2 | TAK-828F (TAK828F) is a novel, potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist with bindingIC50of 1.9 nM and reporter geneIC50of 6.1 nM. |
|
V4586 | TAK-981 | 1858276-04-6 | TAK-981 is a novel, potent and selectivesmall molecule inhibitor of sumoylation with potential immune-activating and antineoplastic activities. |
|
V4589 | TAK1/MAP4K2 inhibitor 1 | 1315330-11-0 | TAK1/MAP4K2 inhibitor 1 is a novel, potent dual TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) inhibitor, withIC50s of 41.1 nM and 18.2 nM, respectively. |
|
V2198 | TC 5115 | 2458182-10-8 | TC 5115(TC-5115) is a novel and potent inhibitor of MLL methyltransferase with IC50 value of 16 nM. |
|
V5133 | Tetrahydrouridine (THU; NSC-112907) | 18771-50-1 | Tetrahydrouridine,a synthetic pyrimidine nucleoside analog, is novel and potent inhibitor of cytidine deaminase (CDA) with biomodulating activity, it competitively blocks the enzyme's active site more effectively than intrinsic cytidine. |
|
V4739 | Tilapertin | 1000690-85-6 | Tilapertin (also known as AMG 747) is a novel, potent and orally bioavailable glycine transporter 1 (GlyT-1) inhibitor with the potential for treatment of schizophrenia. |
|
V4518 | Toreforant | 952494-46-1 | Toreforant (aslo known as JNJ-38518168) is a novel, potent and selective histamine H4receptor (H4R) antagonist with aKiat the human receptor of 8.4 ± 2.2 nM andexcellent selectivity over other receptors including the other histaminereceptors. |
|
V4910 | Tradipitant | 622370-35-8 | Tradipitant (formerly also known as VLY-686 and LY-686017) is novel, potent and 2nd generation neurokinin-1 (NK-1) receptor antagonist, which showed activity in preclinical anxiety models. |
|
V5096 | Triptonide (NSC 165677; PG 492) | 38647-11-9 | Triptonide (NSC-165677; PG-492), a natural product isolated from Tripterygium wilfordii Hook, a novel and potent Wnt/β-catenin inhibitor that inhibited the proliferation of mouse splenocytes induced by suboptimal concentration of concanavalin A or lipopolysaccharide at concentrations of 0.02, 0.1, and 0.5 mg/ml. |
|
V4890 | Trovirdine HCl | 148311-89-1 | Trovirdine HCl (LY-300046 and PETT-1) is a novel and potent reverse transcriptase inhibitor (RTI) that inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate. |
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