New7

Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD
GPCR & G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase Adrenergic Receptor Angiotensin Receptor APJ Bombesin Receptor Bradykinin Receptor cAMP Cannabinoid Receptor CaSR CCK receptor CCR CGRP Receptor CRFR CXCR Dopamine Receptor EBI2 Endothelin Receptor Formyl Peptide Receptor Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor GCGR GHSR GLP Receptor Glucagon Receptor GnRH Receptor GPCR19 GPR GPR109A Guanylate Cyclase Hedgehog(Smoothened) ROCK Histamine Receptor ICMT Leukotriene Receptor LPA Receptor LPL Receptor LTR mAChR Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor MRGPR MT Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor NPY receptor Opioid Receptor OX Receptor Oxytocin Receptor P2Y Receptor PAFR PAR PKD PKG Prostaglandin Receptor Ras RGS Protein S1P Receptor SGLT Sigma Receptor Somatostatin Receptor TAAR TSH Receptor Urotensin Receptor Vasopressin Receptor

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New7

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V4687	PTC299	1256565-36-2	PTC-299 (PTC299; PTC 299) is a novel, potent and orally bioavailableVEGFinhibitorwith potential antiangiogenesis and antineoplastic activities.
V4629	Pulsatilla saponin D	68027-15-6	Pulsatilla saponin D (SB365), a naturally-occurring chemical isolated from the root of Pulsatilla koreana, has been used as a traditional medicine for the treatment of several diseases.
V4623	Rilapladib (SB659032; GTPL7376)	412950-08-4	Rilapladib (formerly aslo known as SB-659032 and GTPL-7376) is a novel, potent and selective lipoprotein-associated phospholipaseA2(Lp-PLA2)inhibitorwith anIC50of 230 pM,also a PAFR (Platelet Activating Factor Receptor) antagonist.
V5164	Rimeporid (EMD 87580)	187870-78-6	Rimeporide (also known as EMD-87580) is a novel, potent and selective inhibitor of the sodium/hydrogen Na+/H+exchanger (NHE-1) with a potential to be used as a therapeutic agent for the treatment of heart failure and for patients with Duchenne muscular dystrophy.
V4624	S-8510	151224-83-8	S-8510 (SB-737552) is a novel and potent partial inverseBenzodiazepine (BDZ) receptoragonist, with Kis of 34.6 nM, 36.2 nM for –GABA and +GABA respectively.
V4736	San78-130	66018-45-9	San78-130 is a novel, potent and selectiveALK1inhibitor with anIC50of 62 nM.
V4749	Satavaptan	185913-78-4	Satavaptan (formerly also known as SR-121463) is a novel, potent and selective vasopressin V2 receptor antagonist that has the potential for the treatment of hyponatremia.
V4606	SB 258719	195199-95-2	SB 258719 (SB-258719) is a novel, potent and selective5-HT7receptorantagonist with apKiof 7.5.
V4616	SB-423562	351490-72-7	SB-423562 is a novel and potent short-acting calcium-sensing receptor(CaR)antagonist.
V4619	SB-568849	395679-53-5	SB-568849 is a novel and potent melanin-concentrating hormone receptor 1(MCH R1) antagonist with apKiof 7.7.
V4621	SB-616234A	908601-49-0	SB-616234A is a novel, potent, selective and orally bioavailable5-HT1B receptorantagonist, with anxiolytic and antidepressant activity.
V4620	SB-7720770 2HCl	607373-46-6	SB-772077B dihydrochloride (also known as SB-772077-B; SB-772077) is a novel and potent aminofurazan-basedRho kinase( ROCK)inhibitor withIC50s of 5.6 nM and 6 nM toward ROCK1 and ROCK2, respevtively.
V4612	SB269652	215802-15-6	SB269652 is a novel and potent drug-like allosteric modulator of the dopamine D2 receptor (D2R).
V4613	SB756050	447410-57-3	SB756050 is a novel, potent and selectiveTGR5agonist which is currently under investigation in phase 1 clinical trials for the treatment of type 2 diabetes.
V4665	Sch-42495	136511-43-8	Sch-42495, the orally bioactive ethylester prodrug of SCH 42354, is a novel and potent inhibitor of neutral metalloendopeptidase (NEP).
V4668	SCH-546738	906805-42-3	SCH-546738 (SCH546738) is a novel, potent selective, and non-competitive CXCR3 antagonist with potential anticancer, immunomodulatory and antiinflammatory activities.
V4672	SCH28080	76081-98-6	SCH-28080 (SCH 28080) is a novel, potent and competitive inhibitor of gastric H+ and K+-ATPase withgastric antisecretory and cytoprotective activities.
V4671	Sch412348	377727-26-9	SCH 412348 (SCH-412348) is a novel and potent competitive antagonists of the human A(2A) receptor (K(i) = 1.1 and 0.6 nM, respectively) with potential anti-PD (Parkinson disease).
V4669	Sch59498	224157-99-7	Sch59498 is a novel and potentphosphodiesterase 1c (Pde1c) inhibitor that has the potentialfor treating or ameliorating an effect of proximal spinal muscular atrophy (SMA) and for preventing or slowing motor neuron death in a subject having SMA.
V5131	SJG-136 (NSC-694501)	232931-57-6	SJG-136 (NSC694501), anovel sequence-selective pyrrolobenzodiazepine (PBD) dimer, is a novel and potent DNA cross-linking/intercalating agent with an XL50of 45 nM for pBR322 DNA; SJG-136 has potent anticancer activity and can be potentially used for the treatment of ovarian cancer and leukemia.