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10mg | ||
25mg | ||
50mg | ||
100mg | ||
250mg |
Purity: ≥98%
SYR127063 (also known as BDBM92454) is a novel, potent and selective HER2 inhibitor with IC50 of 11 nM, 429 nM, > 10000 nM for HER2, EGFR, and HER4, respectively. SYR127063 binds to the active conformation of HER2.
References |
:J Biol Chem. 2011 May 27;286(21):18756-65.
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Molecular Formula |
C23H20CLF3N4O3
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Molecular Weight |
492.8781
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CAS # |
871026-18-5
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SMILES |
FC(C1=CC(OC2=CC=C(NC3=C4N(C=CC4=NC=N3)CCOCCO)C=C2Cl)=CC=C1)(F)F
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InChi Key |
CMMUJJHJYMYOJR-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C23H20ClF3N4O3/c24-18-13-16(4-5-20(18)34-17-3-1-2-15(12-17)23(25,26)27)30-22-21-19(28-14-29-22)6-7-31(21)8-10-33-11-9-32/h1-7,12-14,32H,8-11H2,(H,28,29,30)
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Chemical Name |
2-(2-(4-((3-chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethoxy)ethan-1-ol
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Synonyms |
SYR127063; SYR-127063; SYR 127063; BDBM92454; BDBM-92454; BDBM 92454.
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.0289 mL | 10.1445 mL | 20.2889 mL | |
5 mM | 0.4058 mL | 2.0289 mL | 4.0578 mL | |
10 mM | 0.2029 mL | 1.0144 mL | 2.0289 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.