| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V4639 | NVP-2 | 1263373-43-8 | NVP-2 is a potent and specific ATP-competitive cyclin-dependent kinase 9 (CDK9) probe that can inhibit CDK9/CycT activity with IC50 of 0.514 nM. |
|
V4659 | NVP-BAG956 | 853910-02-8 | NVP-BAG956 (also known as BAG-956) is a novel, potent and ATP-competitivePI3Kinhibitor with anticancer activity. |
|
V4658 | NVP-QAV-572 | 957209-68-6 | NVP-QAV-572 is a novel and potentPI3Kinhibitor (extracted from patent US7998990B2, Compound Example 8) with anIC50of 10 nM. |
|
V2197 | ONO 8430506 | 1354805-08-5 | ONO8430506(ONO-8430506) is a novel and potent autotaxin inhibitor that enhances the antitumor effect of paclitaxel in a breast cancer model. |
|
V4680 | ONO-4057 | 134578-96-4 | ONO-4057 (also known as Ono-LB 457) is a novel, potent and orally bioactive leukotriene B4 receptor antagonist with anIC50of 0.7±0.3 μM. |
|
V5183 | Osajin (CID 95168; NSC 21565) | 482-53-1 | Osajin (CID 95168; NSC 21565), a naturally-occurring compound, is the major bioactive isoflavone isolated from the fruit ofMaclura pomiferawith antitumor, antioxidant and anti-inflammatory activities. |
|
V4804 | PD 117519 | 96392-15-3 | PD 117519 (CI947) is an A2A adenosine agonist with oral anti-hypertensive (blood pressure lowering) activity in pharmacological animal models. |
|
V4803 | PD 90780 | 77422-99-2 | PD 90780 is a novel and potent non peptide antagonist ofnerve growth factor (NGF)which binds to the P75 NGF receptor, and inhibits NGF-p75 NTR interaction withIC50s values of 23.1 µM and 1.8 µM in PC12 cells and PC12 nnr5 cells, respectively . |
|
V4817 | PD-1-IN-17 | 1673560-66-1 | PD-1-IN-17 (structurally similar to CA-170),extracted from patent WO2015033301A1,is a novel and potent inhibitor of programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction, inhibiting 92% splenocyte proliferation at 100 nM. |
|
V4815 | PD-1-IN-18 | 1673534-97-8 | PD-1-IN-18,extracted from WO2015033299A1, is a novel and potent inhibitor of the PD1signaling pathway with potential anticancer activity, it acts as an immunomodulator. |
|
V4816 | PD-1-IN-2898 | 2349372-98-9 | PD-1-IN-2898 (2989 is the last four digits of the CAS #), a [1,2,4]triazolo[4,3- a]pyridine analog, is a novel and potent programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) interaction inhibitor with anIC50of 92.3 nM. |
|
V4805 | PD-118057 | 313674-97-4 | PD-118057 (PD118057) is a novel and potent hERG (Human ether-a-go-go-related gene) channel enhancer. |
|
V4812 | PD-159020 | 177904-00-6 | PD-159020 is a novel, potent, and non-selectiveindole non-peptide antagonist of ETA/ETB (Endothelin)withIC50s of 30 and 50 nM for hETA and hETB, respectively. |
|
V4809 | PD0176078 | 248922-46-5 | PD0176078 is a newly discovered N-type calcium channel (Calcium channel) blocker. |
|
V4807 | PD158780 | 171179-06-9 | PD 158780 is a novel, ATP-competitive and potent EGFR inhibitor withIC50s of 8 pM, 49, 52, 52 nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively. |
|
V4813 | PD173212 | 217171-01-2 | PD173212 is a novel, potent and selective small molecule N-type voltage sensitive calcium channel (VSCC)blocker, with anIC50of 36 nM in IMR-32 assays. |
|
V4814 | PD176252 | 204067-01-6 | PD-176252 is a novel and potent non-peptide antagonist of gastrin-releasing peptide receptor (GRP-R, BB2) and neuromedin B receptor (NMB-R, BB1)with Ki values of 0.17 and 1.0 nM for BB1 and BB2 respectively. |
|
V4759 | Pergafast | 232938-43-1 | Pergafast is a proprietary color developer for thermal paper. |
|
V4983 | PF-06446846 | 1632250-49-7 | PF‑06446846 (PF06446846; PF‑6446846) is a novel and potent PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitor that inhibits the translation of PCSK9 by inducing the ribosome to stall around codon, mediated by the sequence of the nascent chain within the exit tunnel. |
|
V5196 | Phortress HCl (NSC-710305) | 328087-38-3 | Phortress HCl (also known as NSC-710305) is a novel and potent apoptosis stimulant and also a P450 CYP1A1-activated antitumor prodrug with the potential for the treatment of solid tumours. |
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