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    TAK-220
    TAK-220

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V4591
    CAS #: 333994-00-6Purity ≥98%

    Description: TAK-220, a novel 1,4-disubstituted piperidine/piperazine, is a potent, selective and orally bioavailable CCR5 antagonist with IC50s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively. It shows no effect on the binding to CCR1, CCR2b, CCR3, CCR4, or CCR7; TAK-220 also selectively inhibits HIV-1, with EC50s of 1.2 nM (HIV-1 KK), 0.72 nM (HIV-1 CTV), 1.7 nM (HIV-1 HKW), 1.7 nM (HIV-1 HNK), 0.93 nM (HIV-1 HTN), and 0.55 nM (HIV-1 HHA), and EC90s of 12 nM (HIV-1 KK), 5 nM (HIV-1 CTV), 12 nM (HIV-1 HKW), 28 nM (HIV-1 HNK), 15 nM (HIV-1 HTN), and 4 nM (HIV-1 HHA) in PBMCs.

    ReferencesAntimicrob Agents Chemother. 2005 Aug;49(8):3474-82.Antimicrob Agents Chemother. 2005 Aug;49(8):3483-5.

    Related CAS : 333994-00-6 (free base); 674782-27-5 (TAK-220 HCl)

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    TAK-220

    Name: TAK-220
    CAS#: 333994-00-6
    Chemical Formula: C31H41ClN4O3
    Exact Mass: 552.2867
    Molecular Weight: 553.144
    Elemental Analysis: C, 67.31; H, 7.47; Cl, 6.41; N, 10.13; O, 8.68
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: TAK-220, TAK 220, TAK220
    IUPAC/Chemical Name: 1-acetyl-N-[3-[4-[(4-carbamoylphenyl)methyl]piperidin-1-yl]propyl]-N-(3-chloro-4-methylphenyl)piperidine-4-carboxamide
    InChi Key: ASSJTMUEFHUKMJ-UHFFFAOYSA-N
    InChi Code: InChI=1S/C31H41ClN4O3/c1-22-4-9-28(21-29(22)32)36(31(39)27-12-18-35(19-13-27)23(2)37)15-3-14-34-16-10-25(11-17-34)20-24-5-7-26(8-6-24)30(33)38/h4-9,21,25,27H,3,10-20H2,1-2H3,(H2,33,38)
    SMILES Code: O=C(C1CCN(C(C)=O)CC1)N(CCCN2CCC(CC3=CC=C(C(N)=O)C=C3)CC2)C4=CC=C(C)C(Cl)=C4


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