Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Purity: ≥98%
SRT1720 HCl (formerly known as CAY10559 HCl), the hydrochloride salt of SRT1720, is a novel, potent and selective SIRT1 (Sirtuin 1) activator with potential anticancer activity and is a promising new therapeutic agent for treating type 2 diabetes. It activated SIRT1 with an EC50 of 0.16 μM in a cell-free assay, but >230-fold less potentcy against SIRT2 and SIRT3.
ln Vitro |
SRT1720 is a selective activator of SIRT1 with an EC50 of 0.16 μM, which is more than 230 times lower than SIRT2 and SIRT3.
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ln Vivo |
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Animal Protocol |
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References |
Nature.2007 Nov 29;450(7170):712-6;Br J Haematol.2011 Dec;155(5):588-98.
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Molecular Formula |
C25H23N7OS.HCL
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Molecular Weight |
506.02
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CAS # |
1001645-58-4
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Related CAS # |
SRT 1720;925434-55-5
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SMILES |
O=C(NC1=CC=CC=C1C2=CN3C(SC=C3CN4CCNCC4)=N2)C5=NC6=CC=CC=C6N=C5.[H]Cl.[H]Cl
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Chemical Name |
N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide dihydrochloride
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Synonyms |
SRT1720; CAY-10559 HCl; CAY10559; CAY 10559; SRT-1720 HCl, SRT-1720 hydrochloride; SRT1720 HCl; SRT-1720; SRT 1720; SIRT-1933; SIRT 1933; SIRT1933 HCl; CAY-10559;
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.9762 mL | 9.8810 mL | 19.7621 mL | |
5 mM | 0.3952 mL | 1.9762 mL | 3.9524 mL | |
10 mM | 0.1976 mL | 0.9881 mL | 1.9762 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.