Reactive oxygen species (ROS) are radical and non-radical oxygen species produced by the partial reduction of oxygen, including superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•). Endogenous ROS are produced by cells during their normal oxidative metabolism in the mitochondria as well as when they react to xenobiotics, cytokines, and bacterial invasion.
By directly inhibiting MAPK phosphatases, ROS also activates MAPK pathways. Through PTEN, ROS produced by growth factor stimulation are capable of reversibly controlling the redox state of the PI3K pathway. The cellular response to ROS may involve the activation of autophagy.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V72959 | Chlojaponilactone B | 1449382-91-5 | Chlojaponilactone B is an indene-type sesquiterpene with anti-inflammatory activities. |
|
V72900 | Chlorin e6 trimethyl ester | 35038-32-5 | Chlorin e6 trimethyl ester, an analogue of methylpheophorbide-a, is a photosensitizer that may be utilized in photodynamic therapy (PDT). |
|
V72892 | CM-H2DCFDA | 850013-49-9 | CM-H2DCFDA is an analogue of H2DCFDA. |
|
V1873 | Coelenterazine | 55779-48-1 | Coelenterazine, a luciferin which is a light-emitting molecule, is a luminescent enzyme substrate that is used for monitoring reporter genes in BRET, ELISA and HTS techniques. |
|
V72909 | Crocin-4 | 55750-86-2 | Crocin-4, a carotenoid, is a potent and BBB (blood-brain barrier) permeable (penetrable) antioxidant. |
|
V33429 | CycLuc1 | 1247879-16-8 | CycLuc1,a synthetic luciferase substrate, is a brain penetrant luciferase substrate which displays NIR emission. |
|
V72907 | CYPMPO | 934182-09-9 | CYPMPO is a spin trapping agent. |
|
V72915 | D-Isofloridoside | 23202-76-8 | D-Isofloridoside is one of the polysaccharide precursors and has the activity of scavenging free radicals, inhibiting ROS expression, and inhibiting MMP-2 and MMP-9. |
|
V72946 | Danshenol A (danshenol A) | 189308-08-5 | Danshenol A is a rosin diterpenoid and an aldose reductase (AR) inhibitor (antagonist) with IC50 of 0.1 μM. |
|
V72917 | Dehydrocurdione | 38230-32-9 | Dehydrocurdione, a zedoary-derived sesquiterpene, induces heme oxygenase (HO)-1, an antioxidant enzyme, in RAW 264.7 macrophages. |
|
V2768 | Dichloroacetate | 2156-56-1 | Dichloroacetate (CPC-211; DCA; X-11S) isa potent and specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively. |
|
V2871 | Dihydroethidium | 104821-25-2 | Dihydroethidium (formerly known as Hydroethidine and PD-MY 003) is a cell-permeable blue fluorescent dye and a superoxide indicator which exhibits blue-fluorescence in the cytosol until oxidized, where it intercalates within the cell's DNA, staining its nucleus with a bright fluorescent red. |
|
V72925 | Dihydromyristicin | 52811-28-6 | Dihydromyristicin is a plant flavonoid with potent anti-inflammatory activities. |
|
V2213 | Disufenton sodium (NXY-059) | 168021-79-2 | NXY-059 (also known as Cerovive, OKN007, Disufenton Sodium) is a disulfonyl derivative that has shown a significant differences in arterial Po2 and pH between the experimental groups before ischemia in BBB permeability study with Po2 value of 112.9±9.7mm Hg and pH value of 7.443±0.01. |
|
V20134 | DMNQ | 6956-96-3 | DMNQ is a redox cycling agent. |
|
V72880 | DMPO | 3317-61-1 | DMPO is a cell-penetrating/penetrable hydrophilic spin trap for superoxide detection. |
|
V20405 | Efaproxiral (RSR13) | 131179-95-8 | Efaproxiral (RSR13)is a synthetic allosteric modifier of hemoglobin (Hb) andabezafibrate analogused forbrain metastases originating from breast cancer. |
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V1969 | Efaproxiral Sodium (RSR13) | 170787-99-2 | Efaproxiral Sodium(RSR13) is a synthetic allosteric modifier of hemoglobin (Hb) and abezafibrate analog used for brain metastases originating from breast cancer. |
|
V72933 | Efaproxiral-d6 (Efaproxiral-d6) | 1246815-16-6 | Efaproxiral-d6 is the deuterated form of Efaproxiral. |
|
V72929 | Euparin (Zelanin) | 532-48-9 | Euparin is a monomer compound of benzofuran and a reactive oxygen species (ROS) inhibitor. |
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