Reactive oxygen species (ROS) are radical and non-radical oxygen species produced by the partial reduction of oxygen, including superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•). Endogenous ROS are produced by cells during their normal oxidative metabolism in the mitochondria as well as when they react to xenobiotics, cytokines, and bacterial invasion.
By directly inhibiting MAPK phosphatases, ROS also activates MAPK pathways. Through PTEN, ROS produced by growth factor stimulation are capable of reversibly controlling the redox state of the PI3K pathway. The cellular response to ROS may involve the activation of autophagy.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V72908 | Stobadine ((-)-Stobadine) | 85202-17-1 | Stobadine is a potent antioxidant that prevents free radical-induced changes in endoplasmic reticulum membrane fluidity. |
|
V3733 | Succinobucol | 216167-82-7 | Succinobucol (formerly known as AGI-1067, AGZ-1067, Probucol monosuccinate, succinyl ester of probucol) is a a lipid-lowering compound and a phenolic antioxidant with anti-inflammatory and antiplatelet effects. |
|
V72935 | Topo I-IN-1 | 2763655-68-9 | Topo I-IN-1 (Compound 14d) is a Topo I inhibitor (antagonist) with anti-tumor activity and DNA intercalation ability. |
|
V72958 | Topo I/COX-2-IN-2 | 2841455-91-0 | Topo I/COX-2-IN-2 (Compound W10) is a potent dual-target inhibitor of Topo I and COX-2 with IC50s of 0.90 μM and 2.31 μM respectively. |
|
V69217 | Topoisomerase I/II inhibitor 3 | 2770804-74-3 | Topoisomerase I/II inhibitor 3 (7) is a potent dual (bifunctional) inhibitor of topoisomerase I (Topo I) and II (Topo II). |
|
V3251 | TPEN | 16858-02-9 | TPEN (also known as TPED) is a specific cell-permeable heavy metal chelator. |
|
V31525 | trans-Trimethoxyresveratrol | 22255-22-7 | Trans-Trimethoxyresveratrol is an analogue of Resveratrol (RSV), and it may be a more potent anti-inflammatory, antiangiogenic and vascular-disrupting agent when compared with resveratrol. |
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V72913 | Tubulin polymerization-IN-6 | 2768613-52-9 | Tubulin polymerization-IN-6 (compound 5f) is a potent inhibitor of tubulin polymerization with IC50 of 1.09 μM. |
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V71961 | Tyrosinase-IN-12 | 1860779-42-5 | noncompetitive tyrosinase inhibitor (Tyrosinase-IN-12) is a potent, noncompetitive antioxidant and tyrosinase inhibitor (antagonist) with IC50 of 49.33 ± 2.64 µM and a Ki of 31.25 ± 0.25 µM. |
|
V19746 | Visomitin (SKQ-1) | 934826-68-3 | Visomitin (SKQ1; plastoquinonyl decyltriphenyl phosphonium; PDTP) is a higly potent mitochondria-targeted antioxidant and topical cardiolipin peroxidation inhibitor with excellent mitochondrion membrane penetrating ability. |
|
V72885 | Xanthine oxidase | 9002-17-9 | Xanthine oxidase is a xanthine oxidoreductase that generates reactive oxygen species (ROS), catalyzes the oxidation of hypoxanthine to xanthine, and further catalyzes the oxidation of xanthine to uric acid. |
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V80151 | Xanthine oxidase-IN-12 | Xanthine oxidase-IN-12 (Compound 11) is a xanthine oxidase (XO) inhibitor (antagonist) with IC50 of 91 nM. | |
|
V72888 | XJB-5-131 | 866404-31-1 | XJB-5-131 is a ROS and electron scavenger targeting mitochondria. |
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