Reactive oxygen species (ROS) are radical and non-radical oxygen species produced by the partial reduction of oxygen, including superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•). Endogenous ROS are produced by cells during their normal oxidative metabolism in the mitochondria as well as when they react to xenobiotics, cytokines, and bacterial invasion.
By directly inhibiting MAPK phosphatases, ROS also activates MAPK pathways. Through PTEN, ROS produced by growth factor stimulation are capable of reversibly controlling the redox state of the PI3K pathway. The cellular response to ROS may involve the activation of autophagy.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V72960 | Anticancer agent 15 | 2710312-73-3 | Anticancer agent 15 can significantly increase the level of cellular reactive oxygen species ROS and induce melanoma cell death through necroptosis. |
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V72953 | Antioxidant agent-3 | 2710376-48-8 | Antioxidant agent-3 (Compound 14q) is an antioxidant with effective DPPH radical scavenging activity and ABTS+ scavenging activity, with IC50 of 26.58 and 30.31 μM respectively. |
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V78082 | Antitumor photosensitizer-5 | Antitumor photosensitizer-5 (Ru2) is a photosensitizer that effectively targets tumor mitochondria, with IC50 of phototoxicity of 0.3 μM for A549 cells. | |
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V11459 | Apigetrin (Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigenin 7-glucoside) | 578-74-5 | Apigetrin (Apigenin-7-O-β-D-glucopyranoside; Cosmosiin; Apigenin 7-glucoside) is a naturally occuring flavanoid derived from dandelions and exhibits significant anti-proliferative and antioxidant activity, scavengers of ROS. |
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V72970 | Arg-Tyr | 74863-12-0 | Arg-Tyr is a dipeptide with strong hydroxyl radical and hydrogen peroxide scavenging activity. |
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V72949 | Arochlor 1254 | 11097-69-1 | Arolor 1254 is a polychlorinated biphenyl (PCB) mixture containing biphenyl and 54% chlorine. |
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V5205 | Asiaticoside (Madecassol) | 16830-15-2 | Asiaticoside (Madecassol), a novel and naturally occuring trisaccaride triterpene isolated fromCentella asiaticaanda skin whiening agent found in Cetella, suppresses TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts; Asiaticoside shows antioxidant, anti-inflammatory, and anti-ulcer properties. |
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V7475 | ATF6-activator-147 (AA147) | 393121-74-9 | AA147 is an ATF6 simulator. |
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V72894 | Avasopasem manganese (GC-4419; M-40419) | 435327-40-5 | Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase that can quickly and specifically convert O2*- into hydrogen peroxide (H2O2), preventing the initiation of this cascade reaction. |
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V72887 | BNTA | 685119-25-9 | BNTA is a potent extracellular matrix (ECM) modulator that promotes the synthesis of cartilage structural molecules on chondrocytes by activating superoxide dismutase 3 (SOD3). |
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V72962 | Brassicin (Isorhamnetin 7-O-glucoside) | 6743-96-0 | Brassicin, a naturally occurring flavonoid, has free radical scavenging activity. |
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V72898 | Buprofezin (Buprofezin) | 69327-76-0 | Buprofezin is a broad-spectrum insecticide and chitin synthesis inhibitor that targets homopteran pests in their developmental stages. |
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V72934 | Buprofezin-d6 (Buprofezin-d6) | 2140803-94-5 | Buprofezin-d6 is a deuterated marker of Buprofezin. |
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V31947 | CADD522 | 199735-88-1 | CADD522 is a novel and potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM. |
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V31834 | Calycosin-7-O-β-D-glucoside | 20633-67-4 | Calycosin-7-O-β-D-glucoside is an isoflavone extracted from Astragalus membranaceus. |
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V40609 | Camalexin | 135531-86-1 | Camalexin is a naturally occuring indole-based phytoalexin isolated from Camelina sativa and Arabidopsis (Cruciferae) with antibacterial, antifungal, antiproliferative and anticancer activities. |
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V72932 | Capillarisin | 56365-38-9 | Capillarisin, a component of the Artemisia genus, has anti-inflammatory and antioxidant effects. |
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V72957 | Cartap (cartap) | 15263-53-3 | Cartap is an organic nitrogen insecticide that induces significant irreversible Ca2+-dependent contractures in isolated mouse and rabbit neural membrane sheets. |
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V60082 | CHBO4 | 98991-32-3 | CHBO4 is a potent, reversible, competitive, and selective hMAO-B inhibitor with an IC50 value of 0.031 μM in CHBO subseries and an Ki value of 0.010 ± 0.005 μM. |
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V72971 | Chitoheptaose heptahydrochloride | 127171-89-5 | Chitoheptaose hepta HCl is a chitosan oligosaccharide with antioxidant, anti-inflammatory, anti-apoptotic and cardioprotective effects. |
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