Sodium channels are membrane proteins that function as ion channels and transport sodium ions (Na+) across the plasma membrane of cells. They are divided into two categories based on what opens the channel for these ions: voltage changes (for voltage-gated, voltage-sensitive, or voltage-dependent sodium channels, also known as VGSCs or Nav channels), or ligand bindings (for ligand-gated sodium channels). The rising phase of action potentials is caused by sodium channels in excitable cells like neurons, myocytes, and some varieties of glia. There are three different states of voltage-gated Na+ channels: deactivated (closed), activated (open), and inactivated (closed). Instead of a change in membrane potential, ligand-gated sodium channels are activated by the binding of a ligand.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V73718 | Nav1.8-IN-4 | 1620846-16-3 | Nav1.8-IN-4 (compound 9a) is a Nav1.8 channel inhibitor (IC50=0.014 μM). |
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V1655 | Nefopam HCl (Fenazoxine) | 23327-57-3 | Nefopam HCl (Fenazoxine; Leoplexamin; Lenipan; Oxadol; Pallopikeron; Acupan),the hydrochloride salt of nefopam, is a centrally-acting (non-opioid analgesic) painkiller that has been used totreat moderate pain such as muscle pain, joint pain,dental pain, or pain from cancer. |
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V80986 | OD1 | OD1 is a scorpion alpha-toxin that can be extracted from the venom of the Iranian yellow scorpion (Odonthobuthus doriae). | |
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V1665 | Ouabain Octahydrate (Acocantherine) | 11018-89-6 | Ouabain (Ouabain Octahydrate; Acocantherine; G-Strophanthin; Strodival; NSC-25485; NSC25485) is a novel, potent andselective Na+/K+, -ATPase inhibitor with the potential to treat heart failure due to myocardial infarction. |
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V1659 | Oxcarbazepine (GP 47680) | 28721-07-5 | Oxcarbazepine (also known as GP47680; GP-47680, Timox, Trileptal), a sodium channel protein inhibitor, is an anticonvulsant drug used in the treatment of epilepsy. |
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V81064 | Pe1b (μ-TrTx-Pe1b) | Pe1b (μ-TrTx-Pe1b) is a selective Nav1.7 inhibitor (antagonist) with IC50 of 167 nM. | |
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V4427 | PF 04531083 | 1079400-07-9 | PF-04531083 (PF04531083) is a novel, potent and selectiveNaV1.8blocker with the potential to be used for neuropathic/inflammatory pain. |
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V4470 | PF-01247324 | 875051-72-2 | PF-01247324 is a novel, potent, selective and orally bioavailableNav1.8channel blocker with anIC50of 196 nM for recombinant human Nav1.8 channel. |
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V2967 | PF-05089771 | 1235403-62-9 | PF-05089771 (PF05089771) is a potent and subtype selective NaV1.7 inhibitor (IC50 = 11 nM) and Nav1.8voltage-gated sodium channelblocker with the potential to be used in the treatment of chronic neuropathic pain. |
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V3779 | PF-05089771 Tosylate | 1430806-04-4 | PF-05089771 Tosylate, the tosylate salt of PF05089771, is a potent and subtype selective NaV1.7 inhibitor with IC50 of 11 nM. |
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V73706 | PF-05186462 | 1235406-03-7 | PF-05186462 is a potent and specific inhibitor of the human Nav1.7 voltage-dependent sodium channel with IC50 of 21 nM. |
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V4448 | PF-05241328 | 1387633-03-5 | PF-05241328 is a novel, potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channels(Nav1.7), with anIC50of 31 nM. |
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V4453 | PF-06305591 | 1449473-97-5 | PF-06305591 is a novel, potent and highly selective blocker of voltage gated sodium channelNaV1.8with anIC50of 15 nM and with excellent ADME and safety profiles. |
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V73670 | PF-06305591 dihydrate | 2703582-76-5 | PF-06305591 dihydrate is a potent and selective blocker of the voltage-gated sodium channel NaV1.8 with IC50 of 15 nM. |
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V4476 | PF-06869206 | 2227425-05-8 | PF-06869206 (PF06869206) is a novel, potent,selective and orally bioavailable inhibitor of the sodium-phosphate cotransporterNaPi2a(SLC34A1) with the potential to treat CKD. |
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V27441 | Phenazopyridine Hydrochloride | 136-40-3 | Phenazopyridine HCl is alocal analgesic agent used in the urinary tract infections/UTIs to alleviate the pain, irritation, discomfort, or urgency. |
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V1654 | Phenytoin (5,5-Diphenylhydantoin) | 57-41-0 | Phenytoin (also known as NCI-C55765; NCI C55765; NCIC55765; Diphenylhydantoin)is an inactive voltage-gated sodium channel stabilizer that has been approved as an anticonvulsant for the treatment of seizures. |
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V1647 | Phenytoin Sodium | 630-93-3 | Phenytoin Sodium (also known as 5,5-Diphenylhydantoin; Diphenylhydantoin Sodium; Diphantoine), the sodium salt ofPhenytoin, is an inactive voltage-gated sodium channel stabilizer. |
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V81115 | Phlo1a (μ-TrTx-Phlo1a) | Phlo1a (μ-TrTx-Phlo1a) is a bioactive peptide toxin containing 35 amino acid (AA) residues. | |
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V81116 | Phlo1b (μ-TrTx-Phlo1b) | Phlo1b (μ-TrTx-Phlo1b) is a bioactive peptide toxin containing 35 amino acid (AA) residues. |
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